Introduction: Anomalies on probabilistic reasoning, theory of mind (ToM) tasks, and attributional biases have been found in delusional people. Delusions are also effectively modified by cognitive behavioural therapy (CBT). We sought to examine whether CBT reduces delusional conviction by changing such general reasoning anomalies.
Method: Sixteen patients commenced an 8-11 week CBT programme that targeted their delusions. Probabilistic reasoning, attributional biases, and ToM were assessed pre- and post-treatment. Delusional conviction, preoccupation, and distress were rated at each session. Pretreatment task performances were compared to norms. Repeated measures analyses compared pre- and posttreatment task performances and ratings of delusions. Correlational analyses were used to identify factors associated with reduced delusional conviction.
Results: At baseline, 11 patients showed some form of abnormal probabilistic reasoning, 13 excessive attributional biases, and 13 defective ToM compared to norms. Fourteen patients completed the CBT programme and showed significant reductions in delusional conviction and preoccupation. Despite some inconsistent evidence of improvement in verbal ToM tasks, reasoning styles in these 14 patients were largely unchanged by CBT.
Conclusion: Reasoning anomalies associated with delusions in this sample mark a vulnerability that persists and is independent of the effectiveness of CBT.
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http://dx.doi.org/10.1080/13546800801900587 | DOI Listing |
Genes (Basel)
December 2024
Institute for Complex Systems and Mathematical Biology, King's College, University of Aberdeen, Old Aberdeen AB24 3UE, UK.
Background/objectives: A prominent endophenotype in Autism Spectrum Disorder (ASD) is the synaptic plasticity dysfunction, yet the molecular mechanism remains elusive. As a prototype, we investigate the postsynaptic signal transduction network in glutamatergic neurons and integrate single-cell nucleus transcriptomics data from the Prefrontal Cortex (PFC) to unveil the malfunction of translation control.
Methods: We devise an innovative and highly dependable pipeline to transform our acquired signal transduction network into an mRNA Signaling-Regulatory Network (mSiReN) and analyze it at the RNA level.
J Epidemiol Popul Health
January 2025
Service de Santé Publique, Epidémiologie, Economie de la Santé et Prévention, CHU Lille, 59000 Lille, France; UMR1167 RIDAGE, Institut Pasteur de Lille, Inserm, Univ. Lille, CHU Lille, 59000 Lille, France. Electronic address:
Background: Script Concordance Tests (SCTs) represent an innovative assessment method which have been introduced in the 2024 French National Ranking Examinations (EDN). These tests compare a student's clinical reasoning with that of a panel of experts under conditions of uncertainty. Typically, the question involves the impact of new information on an initially proposed hypothesis, with answers given on a Likert scale.
View Article and Find Full Text PDFBehav Brain Sci
January 2025
Department of Anthropology, Durham University, Durham,
The target article explores material culture datasets from three African forager groups. After demonstrating that these modern, contemporary human populations would leave scant evidence of symbolic behaviour or material complexity, it cautioned against using material culture as a barometer for human cognition in the deep past. Twenty-one commentaries broadly support or expand these conclusions.
View Article and Find Full Text PDFBrain Behav
January 2025
Research Institute for Health Sciences and Technologies (SABITA), Neuroscience Research Center, Clinical Electrophysiology, Neuroimaging and Neuromodulation Lab, Istanbul Medipol University, Istanbul, Turkey.
Introduction: The neural substrates of reasoning, a cognitive ability we use constantly in daily life, are still unclear. Reasoning can be divided into two types according to how the inference process works and the certainty of the conclusions. In deductive reasoning, certain conclusions are drawn from premises by applying the rules of logic.
View Article and Find Full Text PDFDev Sci
January 2025
Department of Psychology, University of Waterloo, Waterloo, Ontario, Canada.
Some outcomes are brought about by intentional agents with access to information and others are not. Children use a variety of cues to infer the causes of outcomes, such as statistical reasoning (e.g.
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