In the face of patent expirations at a time of declining innovation across the industry, companies are restructuring their research and development operations and are pursuing an aggressive strategy of acquisitions, licensing deals and research collaborations to boost their drug pipelines.
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iScience
January 2025
Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea.
The heart, with its complex structural and functional characteristics, plays a critical role in sustaining life by pumping blood throughout the entire body to supply nutrients and oxygen. Engineered heart tissues have been introduced to reproduce heart functions to understand the pathophysiological properties of the heart and to test and develop potential therapeutics. Although numerous studies have been conducted in various fields to increase the functionality of heart tissue to be similar to reality, there are still many difficulties in reproducing the blood-pumping function of the heart.
View Article and Find Full Text PDFOpen Res Eur
October 2024
Department of Process and Life Science Engineering, Division of Food and Pharma, LTH, Faculty of Engineering, Lund University, Lund, Skåne County, SE-221 00, Sweden.
Background: The NextFood Project ( www.nextfood-project.eu) started work in 2018 to identify 'Categories of Skills' that students should be equipped with to address the upcoming global challenges within agrifood and forestry disciplines, and involved concepts such as sustainability, technological adaptation and networking.
View Article and Find Full Text PDFEnviron Sci Ecotechnol
January 2025
Global Centre for Environmental Remediation (GCER), College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, 2308, Australia.
Managing plastic waste is one of the greatest challenges humanity faces in the coming years. Current strategies-landfilling, incineration, and recycling-remain insufficient or pose significant environmental concerns, failing to address the growing volume of plastic residues discharged into the environment. Recently, increasing attention has focused on the potential of certain insect larvae species to chew, consume, and partially biodegrade synthetic polymers such as polystyrene and polyethylene, offering novel biotechnological opportunities for plastic waste management.
View Article and Find Full Text PDFChem Sci
January 2025
State Key Laboratory of Powder Metallurgy, Central South University Changsha 410083 P. R. China
In overcoming the barrier of rapid Li transfer in lithium-ion batteries at extreme temperatures, the desolvation process and interfacial charge transport play critical roles. However, tuning the solvation structure and designing a kinetically stable electrode-electrolyte interface to achieve high-rate charging and discharging remain a challenge. Here, a lithium nonafluoro-1-butanesulfonate (NFSALi) additive is introduced to optimize stability and the robust solid electrolyte interface film (SEI), realizing a rapid Li transfer process and the structural integrity of electrode materials.
View Article and Find Full Text PDFAge-related hearing loss affects one-third of the population over 65 years. However, the diverse pathologies underlying these heterogenous phenotypes complicate genetic studies. To overcome challenges associated with accurate phenotyping for older adults with hearing loss, we applied computational phenotyping approaches based on audiometrically measured hearing loss.
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