SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2346668 | PMC |
| http://dx.doi.org/10.1128/AAC.01370-07 | DOI Listing |
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