AI Article Synopsis
- The eye has a unique way of protecting itself from immune responses by utilizing a systemic method rather than the typical delayed-type hypersensitivity (DTH).
- Specialized antigen-presenting cells (APCs) in the eye capture antigens and then travel to the spleen, where they join a specific grouping of immune cells.
- This process leads to the formation of T-regulatory lymphocytes that return to the eye to suppress potential harmful immune reactions.
Article Abstract
The eye possesses a critical method of self-preservation in response to intraocular antigen presentation. Instead of conventional immunity by means of delayed-type hypersensitivity (DTH), the eye participates in a systemic immune response involving the thymus and spleen, ultimately leading to suppression of cell-mediated (T helper 1) immunity. The immune response begins with intraocular capture of antigen by specialized ocular antigen-presenting cells (APCs). These activated APCs then migrate preferentially to the marginal zone of the spleen, where they become part of an intricate and highly specific cluster of immune cells. The end result is the emergence of a population of antigen-specific T-regulatory lymphocytes that return to the eye and suppress DTH.
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| http://dx.doi.org/10.1016/j.cvsm.2007.12.006 | DOI Listing |
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