Objective: This study examined predictive and mediated relationships among youth perception of critical parenting, Child Behavior Checklist Externalizing Subscale (CBCL) externalizing problem scores, adherence, and (hemoglobin A(1c) HbA(1c)), in youth with type 1 diabetes from low socioeconomic status families.
Methods: Caregiver/youth dyads (n = 120) completed diabetes specific measures of family functioning regarding diabetes management and structured adherence interviews. Parents completed the CBCL, while assays of youth HbA(1c) were performed. Analyses were conducted using hierarchical linear regression.
Results: Combined measures predicted 44% of the variance in HbA(1c). Adherence partially mediated critical parenting and HbA(1c), while critical parenting and adherence mediated CBCL externalizing problem scores and HbA(1c). CBCL externalizing problem scores did not mediate critical parenting and HbA1(c).
Conclusions: The presence of youth perceptions of critical parenting and youth externalizing behavior problems may interfere with adherence, leading to increases in HbA(1c).
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http://dx.doi.org/10.1093/jpepsy/jsn012 | DOI Listing |
Background: Anakinra is an interleukin-1 receptor antagonist (IL-1Ra). Since IL-1 has been shown to play a key role in the etiology of different autoinflammatory diseases, blocking its pathway has become an important therapeutic target, even in neonates.
Aims: We aimed to report our experience in using anakinra to treat specific neonatal inflammatory conditions.
Genome organization recapitulates function, yet ciliates like possess highly-specialized germline genomes, which are largely transcriptionally silent. During post-zygotic development, 's germline undergoes large-scale genome editing, rearranging precursor genome elements into a transcriptionally-active genome with thousands of gene-sized nanochromosomes. Transgenerationally-inherited RNAs, derived from the parental somatic genome, program the retention and reordering of germline fragments.
View Article and Find Full Text PDFDev Rev
March 2025
Child Study Center, Yale School of Medicine, 230 S Frontage Rd, New Haven, CT 06519, USA.
Parent-child interactions shape children's cognitive outcomes such that caregivers can guide attention and facilitate learning opportunities. These interactions provide infants and toddlers with rich, naturalistic experiences that engage complex cognitive functions and lay the groundwork for the development of mature executive functions. Although most caregivers seek to engage children optimally, they can unintentionally impede this developmental process by being under-engaged or intrusive.
View Article and Find Full Text PDFHeliyon
January 2025
Departments of Health Informatics, College of Health Sciences, Mattu University, Mattu, Ethiopia.
Background: Child sexual abuse is a grave issue with significant consequences for the well-being and development of children worldwide. Understanding the scope of this problem is essential, particularly in Ethiopia, where protecting the nation's youth is crucial. Although child sexual abuse is a critical issue, there is a lack of comprehensive assessment of its prevalence and associated factors in Ethiopia.
View Article and Find Full Text PDFJ Asthma Allergy
January 2025
Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, 11733, Jordan.
Background: The increasing global prevalence of asthma necessitates effective disease management, with patients and their families playing a central role. Enhancing health literacy (HL) among caregivers is critical to improving asthma outcomes.
Purpose: This study aimed to validate the Arabic version of the Asthma Numeracy Questionnaire (Ar-ANQ) to address the gap in HL assessment tools for Arabic-speaking populations.
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