Effects of diethylstilbestrol (DES), an endocrine disrupting chemical, on abnormal spermatogenesis were studied in adult hamster using daily subcutaneous injection of 0.01, 0.1 and 1.0mg/kg body weight for 1 week. Testicular weight and seminiferous tubular area gradually decreased as dosage increased to 1.0mg/kg DES. Germ cells were rarefied and showed irregular distribution in seminiferous tubules. Apoptosis was pronounced among spermatocytes and spermatids at the 1.0mg/kg dose level. Antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and total antioxide capacity (T-AOC) markedly decreased and malondialdehyde (MDA) concentration significantly increased in the testes. These results suggest that DES (1.0mg/kg) induces testicular oxidative stress and spermatogenic apoptosis in adult male hamsters to extend findings shown for prenatal and/or neonatal exposure.
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