AI Article Synopsis
- Epileptogenesis, or the development of epilepsy, is poorly understood, making prevention strategies challenging.
- Researchers studied the impact of CRE binding transcription factors, specifically CREM and ICER, on epilepsy after inducing status epilepticus in mice using pilocarpine.
- While ICER levels rise post-seizure, it doesn't prevent neuronal damage, but CREM/ICER null mice exhibit significantly worse epilepsy symptoms, indicating that increased ICER may actually help reduce the severity of seizures.
Article Abstract
Alterations in the brain that contribute to the development of epilepsy, also called epileptogenesis, are not well understood, which makes it difficult to develop strategies for preventing epilepsy. Here we have studied the role of the CRE binding transcription factors, cyclic-AMP responsive element modulator (CREM) and inducible cyclic-AMP early repressor (ICER), in the development of epilepsy following pilocarpine induced status epilepticus (SE) in mice. Following SE, ICER mRNA and protein are increased in neurons. The increase in ICER, however, is not necessary for neuronal injury following SE as pilocarpine treatment induces equivalent neuronal injury in pyramidal neurons of wild type and CREM/ICER null mice. Following SE, the CREM/ICER null mice develop a more severe epileptic phenotype experiencing approximately threefold more frequent spontaneous seizures. Together these data suggest that the increase in ICER mRNA following SE may have a role in suppressing the severity of epilepsy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2372160 | PMC |
| http://dx.doi.org/10.1016/j.neuroscience.2007.10.064 | DOI Listing |
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