[Antioxidative defense and level of microelements in youth with hypertension].

Unlabelled: In recent years we observed increased interest of free radical processes accompanying varying physiological and pathological reactions. THE AIM OF THIS STUDY was an evaluation some of serum microelements (zinc, manganium, chromium, selenium) in serum and antioxidative defense in youth with hypertension.

Material And Methods: The group of 88 youth aged 9-18 with normal blood pressure, prehypertension and hypertension was examined. Blood was taken to examine microelements content and antioxidative barrier activity. Microelements content was estimated with the method ICP-AES. Superoxide dismuthase activity in red blood cells was estimate with the method by Misra and Fridovich, glutatione peroxidase activity with the method by Sedlak and Lindsay in modification by Little and O'Brien and catalase activity with the method of Beers and Sizer.

Results: In subgroup with higher blood pressure we observed decreased tendency in enzymatic antioxidant activity (Cat, GSA-Px, SOD) in red blood cells and lowering levels of vitamins C and E in comparison to persons with normal blood pressure. Concentrations of estimated microelements drowed decreased levels in persons with hypertension.

Conclusions: Results of our study suggest that disturbance in pro - and anti-oxidative balance observed in youth with first state of hypertension may play an important role in pathogenesis of hypertension.