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"Click" synthesis of small-molecule inhibitors targeting caspases. | LitMetric

"Click" synthesis of small-molecule inhibitors targeting caspases.

Org Biomol Chem

Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.

Published: March 2008

A panel of 198 P4-diversified aldehyde (reversible) and vinyl sulfone (irreversible) inhibitors is successfully synthesized via an efficient "click chemistry" platform and directly screened against caspase-3 and -7 for inhibition.

Download full-text PDF

Source
http://dx.doi.org/10.1039/b718304fDOI Listing

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