AI Article Synopsis
- The study compared oesophageal function between patients with erosive esophagitis, non-erosive reflux disease, and healthy controls using manometry and impedance measurements.
- Healthy individuals demonstrated stronger peristaltic movements and more consistent bolus transit compared to both patient groups.
- Erosive esophagitis was linked to increased transit times and reduced bolus transit completion, suggesting that worsening mucosal damage may contribute to these functional differences.
Article Abstract
Background: We determined any difference in oesophageal function between reflux patients with and without erosive esophagitis by the application of concurrent manometry and impedance.
Methods: Twenty patients with erosive esophagitis, 20 patients with non-erosive reflux disease, and 15 controls were included in this study. All subjects underwent studies with a catheter containing four impedance-measuring segments and five solid-state pressure transducers. Each subject received 10 liquid and 10 viscous boluses to be swallowed.
Results: Healthy controls had greater distal oesophageal peristaltic amplitude than both patient groups (p < 0.05). Normal oesophageal peristalsis was found more frequently in healthy controls than either of the patient groups (p < 0.05). Patients with erosive esophagitis exhibited a lower percentage of complete bolus transit compared to healthy controls and non-erosive reflux disease patients (both p < 0.05). Patients with erosive esophagitis had a longer total bolus transit time compared to healthy controls and non-erosive reflux disease patients (both p < 0.05).
Conclusions: Erosive esophagitis is characterized by longer oesophageal bolus transit and fewer complete bolus transit than non-erosive reflux disease. The noted differences in oesophageal bolus transit may reflect a continuum of dysfunction secondary to increasing oesophageal mucosal damage.
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| http://dx.doi.org/10.1016/j.dld.2007.12.017 | DOI Listing |
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