AI Article Synopsis
- C-IRIV/PTR-4 is an innovative cancer vaccine that combines immune-reconstituted influenza virosomes with a peptide that triggers a specific immune response against PTH-rP, showing promise in lab studies with mice.
- In experiments, C-IRIV/PTR-4 demonstrated similar immune responses to a soluble form of the peptide but offered enhanced tumor suppression and an additional effect against blood vessel formation in tumors.
- The findings indicate that C-IRIV/PTR-4 may be a more effective treatment option for cancers like breast, prostate, and lung that often over-express the target antigen, PTH-rP.
Article Abstract
Background: C-IRIV/PTR-4 is a novel anticancer vaccine construct composed of immune-reconstituted influenza virosomes (IRIV) assembled with the PTH-rP derived peptide (PTR)-4, a synthetic CTL epitope with HLA-A(*)02.01 amino acid binding motifs. This peptide is able to generate a human PTH-rP specific CTL response with anti-tumor activity in vitro and in mice.
Materials And Methods: We have investigated the immunological and preventive anti-tumor activity of C-IRIV/PTR-4 compared with the soluble PTR-4 peptide, in HHD mice inoculated with autologous PTH-rP+ tumor cells.
Results: Peptide vaccination with either a soluble and an IRIV formulation showed similar immunological activity and the ability to purge the tumor tissue of tumor cell clones able to produce the target antigen (PTR-rP). The most efficient protection from tumor growth was however observed in animals vaccinated with C-IRIV/PTR-4 in which an additional IRIV related anti-angiogenetic effect was detected in the tumor tissue.
Conclusions: These results confirm the immunological activity of PTR-4 vaccination and suggest a more efficacious therapeutic potential of C-IRIV/PTR-4 against bone metastases and malignancies like breast, prostate and lung which very often over-express PTH-rP.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.canlet.2008.01.018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!