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Investigating the Relationship Between Anti-seizure Medications and Bleeding Disorders: A Comprehensive Review of the Current Literature.
Drugs Real World Outcomes
January 2025
Kabul University of Medical Sciences, Kabul, Afghanistan.
Anti-seizure medications (ASMs) are specific types of anticonvulsants used to treat epileptic seizures. However, several studies have shown an association between ASMs and an increased risk of hematological disorders, such as thrombocytopenia, aplastic anemia, and platelet function disorders leading to prolonged bleeding times. This review explores the existing literature on this topic, investigating a wide variety of ASMs, ranging from first-generation medications to newer ones.
View Article and Find Full Text PDFThe effects of gabapentin and pregabalin on fracture healing: A histological, radiological, and biomechanical analysis.
Jt Dis Relat Surg
January 2025
Balıkesir Üniversitesi Tıp Fakültesi Ortopedi ve Travmatoloji Anabilim Dalı, 10185 Altıeylül, Balıkesir, Türkiye.
Objectives: This study evaluated the impact of different doses of gabapentin and pregabalin on fracture healing in a rat femoral shaft model, with histological, radiological, and biomechanical assessments.
Materials And Methods: Seventy male Wistar albino rats were divided into five groups: control, low-dose gabapentin (GBP-L, 300 mg/day), high-dose gabapentin (GBP-H, 3600 mg/day), low-dose pregabalin (PRG-L, 150 mg/day), and high-dose pregabalin (PRG-H, 600 mg/day), based on human equivalent doses. Bilateral femoral fractures were induced; the right femurs were prepared for radiological examination using microtomography, followed by histological analysis, whereas the left femurs were allocated for biomechanical testing.
Ethanolic Extracts of Linn. (Vitaceae) Attenuate Vincristine-Induced Peripheral Neuropathy in Rats: An Evidence of the Antioxidant, Calcium Inhibitory, and Neuromodulatory Properties.
Adv Pharmacol Pharm Sci
December 2024
Laboratory of Animal Physiology and Phytopharmacology, Department of Animal Biology, Faculty of Science, University of Dschang, Dschang, Cameroon.
Linn. (, Vitaceae) is a plant reported to treat injured tendons, broken bones, asthma, stomach ache, scurvy, and digestive disorders. The present study evaluated the antihyperalgesic effects of ethanolic extract of Linn.
View Article and Find Full Text PDFEfficacy of Higher-Voltage Long-Duration Pulsed Radiofrequency for Spinal Zoster-Associated Pain: A Randomized Controlled Trial.
Pain Physician
December 2024
Department of Pain Management, West China Hospital/West China Tianfu Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Article Synopsis
- The study evaluates the safety and effectiveness of a higher-voltage long-duration pulsed radiofrequency (HL-PRF) treatment for managing zoster-associated pain (ZAP) compared to standard treatment.
- Patients in Group A received gradually increased voltage up to 100 V, while Group B maintained a steady 65 V throughout.
- Results focused on pain levels, emotional well-being, and quality of life over 12 weeks, with an aim to address high recurrence rates associated with the existing methods.
A randomized, double-blind, placebo controlled study to evaluate the effect of alpha-lipoic acid on inhibition of ADP-and collagen-induced platelet aggregation ex vivo in diabetic neuropathy patients on gabapentin or pregabalin.
J Postgrad Med
October 2024
Department of Clinical Pharmacology and Therapeutics, NIMS, Hyderabad, Telangana, India.
Background: Diabetic peripheral neuropathy (DPN) is a chronic microvascular complication in diabetic mellitus patients due to chronic hyperglycemia, resulting in platelet hyperactivity and dyslipidemia. Alpha-lipoic acid (ALA) is a potent antioxidant which has antiplatelet activity and lipid-modulating characteristics and plays a major role in the prevention of disease progression.
Aim: To evaluate the effect of ALA on inhibition of platelet aggregation and lipid profile.
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