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Consensus outcomes between health professionals and parents for oral corticosteroids in treating preschool wheeze: a multi-national survey and nominal group technique study.
Arch Dis Child
January 2025
Department of Child Life and Health, University of Edinburgh Institute for Regeneration and Repair, Edinburgh, UK.
Objective: To obtain priority consensus for outcome measures of oral corticosteroid treatment of preschool wheeze that represent stakeholder groups.
Design: (1) A systematic review to identify a set of outcome measures; (2) an international survey for healthcare professionals (HCPs) and a nominal group meeting with parents; (3) a final consensus nominal group meeting with key HCPs (trial investigators and paediatric emergency medicine clinicians) and the same parent group.
Main Outcome Measures: Consensus priority of treatment outcome measures, outcome minimal clinically important differences (MCIDs) and level of concerns about adverse effects.
Comparative 3D ultrastructure of Plasmodium falciparum gametocytes.
Nat Commun
January 2025
Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Despite the enormous significance of malaria parasites for global health, some basic features of their ultrastructure remain obscure. Here, we apply high-resolution volumetric electron microscopy to examine and compare the ultrastructure of the transmissible male and female sexual blood stages of Plasmodium falciparum as well as the more intensively studied asexual blood stages revisiting previously described phenomena in 3D. In doing so, we challenge the widely accepted notion of a single mitochondrion by demonstrating the presence of multiple mitochondria in gametocytes.
View Article and Find Full Text PDFOral Food Challenge Protocols in Food Protein-Induced Enterocolitis Syndrome: A Systematic Review.
J Allergy Clin Immunol Pract
December 2024
Section of Inflammation, Repair and Development, National Heart and Lung Institute. Imperial College London, London, UK. Electronic address:
Background: Oral Food Challenges (OFC) are essential for the diagnosis and follow-up of acute Food Protein-Induced Enterocolitis Syndrome (FPIES) because no diagnostic or prognostic biomarkers are available. However, the optimal OFC procedure remains unclear.
Objectives: This systematic review aimed to assess OFC procedures' design and clinical outcomes in patients with FPIES.
Current status and influencing factors of missing appointments in patients with periodontitis: a cross-sectional study.
BMC Oral Health
December 2024
Department of Periodontology, Nanjing Stomatological Hospital Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Aim: This study aims at analyze the current status and influencing factors of missing appointments in patients with periodontitis after supragingivgy scaling, and to explore the measures to reduce the rate of missing appointments, so as to provide a reference for the prevention of periodontitis and oral health promotion.
Methods: This study adopted convenience sampling method to select 204 patients who made appointments for revisits in Grade III and Grade A stomatological hospitals in Guizhou Province from May 2021 to May 2022 as the study objects, and conducted the investigation by general data questionnaire, patient satisfaction questionnaire and modified Dental Anxiety Scale (MDAS).
Results: The rate of missing appointments in patients with periodontitis was 64.
Revisiting microgenderome: detecting and cataloguing sexually unique and enriched species in human microbiomes.
BMC Biol
December 2024
Computational Biology and Medical Ecology Lab, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Background: Microgenderome or arguably more accurately microsexome refers to studies on sexual dimorphism of human microbiomes aimed at investigating bidirectional interactions between human microbiomes, sex hormones, and immune systems. It is important because of its implications to disease susceptibility and therapy, in which men and women demonstrate divergence in many diseases especially autoimmune diseases. In a previous report [1], we presented analyses of several key ecological aspects of microgenderome by leveraging the large datasets of the HMP (human microbiome project) but failed to offer species-level composition differences such as sexually unique species (US) and enriched species (ES).
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