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Neurotoxin-Derived Optical Probes for Elucidating Molecular and Developmental Biology of Neurons and Synaptic Connections : Toxin-Derived Optical Probes for Neuroimaging.
Mol Imaging Biol
December 2024
Faculty of Engineering and Science, University of Greenwich London, Chatham Maritime, Kent, ME4 4TB, UK.
Article Synopsis
- * Researchers are using modified forms of BoNTs and TeTX, labeled with reporter proteins and fluorophores, to visualize and study cellular processes in neurons, enhancing our understanding of synaptic functions.
- * The study discusses advanced optical probes made from these toxins, their design, applications in molecular biology and neurodevelopment, advantages, limitations, and future potential, highlighting their role in neuroimaging and neuroscience advancements.
The role of zinc and matrix metalloproteinases in myofibrillar protein degradation in critical illness myopathy.
Free Radic Biol Med
September 2024
Department of Physiology and Pharmacology, Karolinska Institutet Bioclinicum, Stockholm, 171 64, Sweden; Center for Molecular Medicine (CMM), Karolinska Institutet, Stockholm, 171 76, Sweden; Viron Molecular Medicine Institute, Boston, MA, 02108, United States. Electronic address:
Due to an unexpected activation of different zinc (Zn) transporters in a recent prospective clinical study, we have revisited the role of Zn homeostasis and the activation of matrix metalloproteinases (MMPs) in skeletal muscle exposed to the intensive care unit (ICU) condition (immobilization and mechanical ventilation). ICU patients exposed to 12 days ICU condition were followed longitudinally with six repeated muscle biopsies while they showed a progressive preferential myosin loss, i.e.
View Article and Find Full Text PDFRevisiting large complex ventral hernia repair: multimodal hybrid technique deploying preoperative Botulinum Toxin A injection, laparoscopic anterior components separation and open mesh repair.
Updates Surg
October 2024
General & Colorectal Surgery Department, Luton & Dunstable University Hospital NHS Trust, Luton, Bedfordshire, UK.
In the past, various techniques had been described to repair large complex ventral hernias. Laparoscopic technique of components separation showed low complication rates and better overall outcome. Recently, Botulinum Toxin A (BTA) has shown benefit in achieving tension-free repair.
View Article and Find Full Text PDFRevisiting rabbit models for keratoconus: A long-term study on collagenase-induced disease progression.
Exp Eye Res
April 2024
Centre for Ocular Regeneration, Prof. Brien Holden Eye Research Centre, Champalimaud Translational Centre for Eye Research, L.V. Prasad Eye Institute, Hyderabad, Telangana, India. Electronic address:
Keratoconus (KC) is a degenerative disorder resulting from the degradation of the stromal collagen fibril network in the cornea, leading to its thinning and conical deformation. Various studies have established animal models of KC by using the collagenase type II enzyme to gain a better understanding of the pathogenesis, however, long-term monitoring or follow-up of the models have not been reported so far. This study evaluates the long-term stability of collagenase type II-induced KC in a rabbit model.
View Article and Find Full Text PDFThe protease ADAM17 at the crossroads of disease: revisiting its significance in inflammation, cancer, and beyond.
FEBS J
January 2024
Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Vic., Australia.
The protease A Disintegrin And Metalloproteinase 17 (ADAM17) plays a central role in the pathophysiology of several diseases. ADAM17 is involved in the cleavage and shedding of at least 80 known membrane-tethered proteins, which subsequently modulate several intracellular signaling pathways, and therefore alter cell behavior. Dysregulated expression and/or activation of ADAM17 has been linked to a wide range of autoimmune and inflammatory diseases, cancer, and cardiovascular disease.
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