AI Article Synopsis
- The study aimed to identify distinct subtypes of depression in patients with Alzheimer's disease and categorize them based on their symptoms.
- A latent class analysis was performed on 306 Alzheimer’s patients using the Cornell Scale for Depression in Dementia, revealing four subgroups: asymptomatic, mild depression, severe depression, and a group with significant anxiety and irritability.
- Results suggest that some Alzheimer’s patients exhibit depression patterns similar to younger adults, while a unique subtype with notable anxiety and irritability may also exist.
Article Abstract
The purpose of this study was to evaluate whether distinct subtypes of depression could be identified in patients with Alzheimer's disease and, if so, to evaluate the patients in these subgroups. Ratings on the Cornell Scale for Depression in Dementia (CSDD) of 306 patients with Alzheimer's disease, 129 of whom were Spanish- and 177 English-speaking, were subjected to latent class analysis. Four subgroups were identified based on CSDD symptoms. These included an asymptomatic group, groups with mild and more severe typical depression, and a group characterized by prominent anxiety and irritability in addition to sadness. Group differences on demographic, cognitive, clinical, and functional status measures were explored via chi-square tests and analyses of variance. Results show that for some patients with Alzheimer's disease, patterns of symptoms of depression are similar to those in younger adult populations. A distinct subtype may exist, however, with prominent anxiety and irritability.
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| http://dx.doi.org/10.1177/0891988707311564 | DOI Listing |
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