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Triplex H-DNA structure: the long and winding road from the discovery to its role in human disease.
NAR Mol Med
October 2024
Department of Biology, Tufts University, 200 Boston Ave., Medford, MA 02155, USA.
H-DNA is an intramolecular DNA triplex formed by homopurine/homopyrimidine mirror repeats. Since its discovery, the field has advanced from characterizing the structure to discovering its existence and role . H-DNA interacts with cellular machinery in unique ways, stalling DNA and RNA polymerases and causing genome instability.
View Article and Find Full Text PDFEffects of Hygrothermal Condition on Water Diffusion and Flexural Properties of Carbon-Glass Hybrid Fiber-Reinforced Epoxy Polymer Winding Pipes.
Polymers (Basel)
December 2024
School of Civil Engineering, Harbin Institute of Technology (HIT), 73 Huanghe Road, Nangang District, Harbin 150090, China.
Carbon-glass hybrid fiber-reinforced epoxy polymer (C-GFRP) winding pipes integrated with the advantages of light weight, high strength, corrosion resistance, and cost-effectiveness offer immense potential to mitigate corrosion issues in oil, gas, and water transportation pipelines. In this study, C-GFRP winding pipes underwent accelerated aging tests through immersion in distilled water at temperatures of 25 °C, 40 °C, and 60 °C for 146 days. Water absorption tests were conducted to investigate the water absorption behavior of only CFRP- or GFRP-side absorbed water.
View Article and Find Full Text PDFFrom cancer to pluripotent stem cells-A long and winding road.
Bioessays
December 2024
The Centre for Stem Cell Biology, The School of Biosciences, The University of Sheffield, Sheffield, UK.
: Three-year Mortality Following Prescription of Multidrug Antibiotic Treatment for Pulmonary Disease in United States Medicare Beneficiaries With Bronchiectasis.
Open Forum Infect Dis
November 2024
Division of Infectious Diseases, Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Background/aims: Although increased mortality has been reported among people with pulmonary disease (MAC-PD), data are limited on survival associated with various antibiotic regimens used to treat MAC-PD. We conducted a comparative analysis of 3-year mortality in Medicare beneficiaries with bronchiectasis using various MAC-PD regimens.
Methods: We included Medicare beneficiaries aged ≥65 years with bronchiectasis (01/2006-12/2014).
Optic flow density modulates corner-cutting in a virtual steering task for younger and older adults.
Sci Rep
November 2024
Rochester Institute of Technology, Center for Imaging Science, Rochester, NY, 14620, USA.
There is a critical need to understand how aging visual systems contribute to age-related increases in vehicle accidents. We investigated the potential contribution of age-related detriments in steering based on optic flow, a source of information known to play a role in navigation control. Seventeen younger adults (mean age: 21.
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