Synthesis of indole-3-carboxylic acid derivatives by Pd(0)-catalyzed intramolecular alpha-arylation of beta-(2-iodoanilino) esters.

J Org Chem

Laboratori de Química Orgànica, Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, 08028-Barcelona, Spain.

Published: March 2008

beta-(2-Iodoanilino) esters undergo intramolecular alpha-arylation in the presence of Pd(PPh(3))(4) and potassium phenoxide. The reaction is a useful methodology for the preparation of indole-3-carboxylic acid ester derivatives.

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Source
http://dx.doi.org/10.1021/jo800034mDOI Listing

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