AI Article Synopsis
- The study compares protein profiles from 37 breast cancer surgical tissues, focusing on tumor-derived proteins while excluding blood-derived ones.
- A significant 39% of these proteins were common across all patients, including important enzymes and proteins related to stress response and cancer progression.
- Some proteins showed inconsistent presence but high expression levels, indicating their potential use for categorizing patients based on treatment strategies.
Article Abstract
In the present study, we report the comparative proteome profiles of proteins solubilized from 37 breast cancer surgical tissues, normalized for the actin content. Blood-derived proteins were excluded from the analysis. Among the tumor-derived protein spots, a large proportion (39%) was found present in all patients. These included several glycolytic enzymes, detox and heat shock proteins, members of annexin and S100 protein families, cathepsin D, and two "rare" proteins, DDAH2 involved in the angiogenesis control, and the oncogene PARK7. Other proteins, such as psoriasin, galectin1, cofilin, peroredoxins, SH3L1, and others, showed sporadic presence and high expression level, which suggests their possible role for patient stratification.
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| http://dx.doi.org/10.1021/pr700748m | DOI Listing |
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