The epidemic of methamphetamine dependence is spreading eastward across the United States. Unlike the gender ratio associated with most other drugs of abuse, the proportion of woman methamphetamine users is nearly equal to men. This review will describe reasons why women begin use of methamphetamine, especially those that differ from the usual reasons for initiating drug use. The characteristics of women users at entry into treatment also differ from those of men, especially in regard to employment, psychological symptoms, and history of abuse and violence in their lives. Finally, the review will address treatment issues and options that can be responsive to the distinctive needs of women dependent on methamphetamine.
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Article Synopsis
- Addiction is a chronic brain disease associated with drug-seeking behavior, and Flos Daturae (FD) is being studied for its potential in addiction treatment, although its effective components are not well understood.
- The study aimed to investigate the impact of individual ingredients in FD on methamphetamine addiction, utilizing advanced techniques like LC-MS/MS, molecular docking, and behavioral experiments to identify specific targets and mechanisms.
- Findings revealed that pinoresinol (PINL), a key component of FD, effectively reduced methamphetamine-seeking behavior by specifically targeting the D1 dopamine receptor and its associated pathways, suggesting a targeted approach for addiction treatment.
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