Prostate cancer is one of the common cancers in old men. Androgen ablation is a major option for the treatment of the metastatic diseases. However, most of the cancers progress to a more aggressive stage, so-called androgen-independent (or hormone refractory) relapse beyond any cure. The androgen receptor (AR) is an important factor in regulating the differentiation and proliferation of prostate epithelial cells, and also plays a critical role in cellular survival. Studies have demonstrated that aberrant activation of the AR is a major determinant in prostate cancer progression. We have provide a brief summary of AR-mediated cellular survival and an introduction to the advances of RNA interference techniques in silencing AR expression as a novel therapy for prostate cancer.
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