AI Article Synopsis
- SR-9g, a compound called 1H-tetrazole-1-alkanenitrile, is more than 10 times more effective in living organisms than its predecessor, nitrile 1.
- It has been shown to have good oral bioavailability in tests with rats and dogs.
- Researchers have created a specific method to synthesize this compound, focusing on producing distinct enantiomers of 1H-tetrazole-1-alkanenitrile nitriles.
Article Abstract
1H-tetrazole-1-alkanenitrile SR-9g exhibits a >10-fold in vivo potency enhancement over the lead nitrile 1 and has acceptable oral bioavailability in rats and dogs. An enantiospecific synthesis of 1H-tetrazole-1-alkanenitrile nitriles 9 has been developed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2008.01.100 | DOI Listing |
Publication Analysis
Top Keywords
optimization 1h-tetrazole-1-alkanenitriles
4
1h-tetrazole-1-alkanenitriles potent
4
potent orally
4
orally bioavailable
4
bioavailable growth
4
growth hormone
4
hormone secretagogues
4
secretagogues 1h-tetrazole-1-alkanenitrile
4
1h-tetrazole-1-alkanenitrile sr-9g
4
sr-9g exhibits
4
Similar Publications
Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues.
Bioorg Med Chem Lett
March 2008
Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA.
Article Synopsis
- SR-9g, a compound called 1H-tetrazole-1-alkanenitrile, is more than 10 times more effective in living organisms than its predecessor, nitrile 1.
- It has been shown to have good oral bioavailability in tests with rats and dogs.
- Researchers have created a specific method to synthesize this compound, focusing on producing distinct enantiomers of 1H-tetrazole-1-alkanenitrile nitriles.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!