AI Article Synopsis
- Aquaporin (AQP)1 is a water channel protein found in various organs, characterized by two NPA motifs and belonging to a family of 13 known human AQPs.
- AQP1 is primarily responsible for transporting water molecules, while other AQPs may also transport glycerol and small solutes.
- The text also highlights proteomic methods for studying AQP1, especially through techniques like mass spectrometry, and discusses its significance in human diseases, particularly its involvement in kidney tumors.
Article Abstract
Aquaporin (AQP)1 belongs to a ubiquitous family of water channel proteins characterized by sequence similarity and the presence of two NPA (Asp-Pro-Ala) motifs existing in almost all organs and tissues. Currently, 13 human AQPs are known and they are divided into two subgroups according to their ability to transport only water molecules, such as AQP1, or also glycerol and other small solutes. The genomic, structural and functional aspects of AQP1 are briefly described. An in-depth discussion is devoted to proteomic approaches that are useful for identifying and characterizing AQP1, mainly through electrophoretic techniques combined with different extraction procedures followed by mass spectrometry analysis. Moreover, the relevance of AQP1 in human diseases is also explained. Its role in human tumors and, in particular, those of the kidney (e.g., clear cell renal carcinoma) is discussed.
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| http://dx.doi.org/10.1586/14789450.5.1.29 | DOI Listing |
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