AI Article Synopsis
- Autophagy helps cells recycle and degrade damaged organelles, especially during nutrient scarcity.
- This study finds that low oxygen levels (hypoxia) trigger mitochondrial autophagy, which relies on specific proteins like BNIP3, Beclin-1, and Atg5.
- Prolonged hypoxia leads to mitochondrial autophagy being a protective mechanism, reducing cell death by controlling reactive oxygen species levels.
Article Abstract
Autophagy is a process by which cytoplasmic organelles can be catabolized either to remove defective structures or as a means of providing macromolecules for energy generation under conditions of nutrient starvation. In this study we demonstrate that mitochondrial autophagy is induced by hypoxia, that this process requires the hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxia, mitochondrial autophagy is an adaptive metabolic response which is necessary to prevent increased levels of reactive oxygen species and cell death.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447655 | PMC |
| http://dx.doi.org/10.1074/jbc.M800102200 | DOI Listing |
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