AI Article Synopsis
- Gyromitrin is a toxin found in the wild mushroom Gyromitra esculenta, which can affect human health.
- When exposed to acidic conditions that mimic the human stomach, gyromitrin is converted into methylhydrazine, a compound known to cause tumors in some animals.
- This process raises concerns about the carcinogenic and acute toxicity risks associated with eating G. esculenta.
Article Abstract
Gyromitrin, acetaldehyde N-methyl-N-formylhydrazone, is a toxin present in edible wild mushroom Gyromitra esculenta. At 37 degrees under different acidic conditions (pH 1 to 3), mimicking the milieu of human stomach, gyromitrin is converted to methylhydrazine, a known tumor inducer in mice and hamsters, through an intermediate, N-methyl-N-formylhydrazine. In addition, methylhydrazine is formed in the mouse stomach after p.o. administration of gyromitrin. These findings imply that consumption of G. esculenta could present a carcinogenic, as well as an acutely toxic, health hazard.
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