AI Article Synopsis
- The NLR family plays a significant role in regulating inflammation and innate immune responses in both plants and animals, with potential functions extending beyond just immunity.
- Recent research highlights NLR proteins' involvement in controlling key pathways like IL-1 and NF-kappaB and their response mechanisms to various pathogens and forms of cell death.
- The review also explores the biochemical properties of NLRs, their regulation by molecules like ATP and proteins like HSP90, and their connections to processes such as inflammasome formation and specific cell death pathways like pyroptosis and necrosis.
Article Abstract
The NLR (nucleotide-binding domain leucine-rich repeat containing) family is found in plants and animals, and serves as crucial regulators of inflammatory and innate immune response, though its functions are likely to extend greatly beyond innate immunity, and even beyond the immune system. This review discusses recent findings regarding the function of NLR proteins in the control of IL-1, NF-kappaB, and host response to pathogens including distinct forms of cell death. The review also covers recent advances regarding the biochemical nature of NLRs, its regulation by intracellular nucleotides and extracellular ATP, by the chaperone protein HSP90, and the ubiquitin ligase-associated protein SGT1. Its role in inflammation is linked to the formation of biochemical complexes such as the inflammasome, and its roles in cell death might be linked to the proposed formation of pyroptosome and necrosome.
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| http://dx.doi.org/10.1016/j.coi.2008.01.003 | DOI Listing |
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