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Article Synopsis
- - The study investigates the link between eosinophilia and ocular vascular issues, highlighting the procoagulant effects of eosinophils, which can lead to various cardiovascular problems and eye conditions.
- - A retrospective, multicenter analysis of 57 patients revealed that the majority experienced eye issues as the first sign of eosinophil-related diseases, with specific conditions like central retinal artery occlusion being common among them.
- - The findings indicate a poor visual prognosis for these patients, with only 10% achieving full recovery, suggesting the need for urgent treatment and further research on eosinophilia's impacts.
Dual MPO/PR3 ANCA positivity and vasculitis: insights from a 7-cases study and an AI-powered literature review.
Rheumatology (Oxford)
September 2024
LBAI Inserm UMR 1227, Univ Brest, Brest, France.
Objectives: Anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitides (AAV) are rare conditions characterized by inflammatory cell infiltration in small blood vessels, leading to tissue necrosis. While most patients with AAV present antibodies against either myeloperoxidase (MPO) or proteinase 3 (PR3), rare cases of dual positivity for both antibodies (DP-ANCA) have been reported, and their impact on the clinical picture remains unclear. The goal of this study was to investigate the clinical implications, phenotypic profiles and outcomes of patients with DP-ANCA.
View Article and Find Full Text PDFTakayasu arteritis and primary sclerosing cholangitis: A casual association or different phenotypes of the same disease?
J Transl Autoimmun
September 2021
Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milan Bicocca, Milan, Italy.
Takayasu arteritis and primary sclerosing cholangitis are two rare disorders. The pathogenesis of Takayasu arteritis involves immune-mediated mechanisms, and corticosteroids represent the mainstay for treatment. Conversely, the aetiology of primary sclerosing cholangitis remains elusive, even if dysimmunity seems to be one of the contributors to bile duct damage.
View Article and Find Full Text PDFImproving benefit-harm assessment of glucocorticoid therapy incorporating the patient perspective: The OMERACT glucocorticoid core domain set.
Semin Arthritis Rheum
October 2021
Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia, Rheumatology Research Group, Basil Hetzel Institute, Adelaide, Australia, Adelaide Medical School, University of Adelaide, Adelaide, Australia. Electronic address:
Objective: Our primary objective was to develop an Outcome Measures in Rheumatology (OMERACT) core domain set to capture the impact of glucocorticoids (GC), both positive and negative, on patients with Rheumatic conditions.
Methods: The OMERACT Filter 2.1 was used to guide core domain selection.
Low dose IL-2 in patients with steroid-dependent dysimmune manifestations associated with myelodysplastic syndromes: a three-case report.
Rheumatology (Oxford)
July 2021
Service de Médecine Interne, IUCT Oncopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse.
Article Synopsis
- - Systemic inflammatory and autoimmune diseases can occur alongside myelodysplastic syndromes, and current treatments like steroids and biologics are not very effective due to their low response rates and side effects.
- - This study treated three patients with myelodysplastic syndromes and autoimmune disorders using low doses of IL-2, aiming to stimulate regulatory T-cells and reduce reliance on steroids.
- - Results showed clinical improvement and a reduction in steroid use for 2 out of 3 patients, with no serious side effects or disease progression, indicating potential for further research on IL-2 in this context.
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