Objective: To investigate the clinical characteristics of temporomandibular joint osteoarthrosis (TMJOA) in patients with malocclusion before orthodontic treatment and evaluate the radiographic changes of temporomandibular joint during treatment.
Methods: Complete clinical recordings of 10,032 patients referring to the Orthodontic Department of Peking University School and Hospital of Stomatology from January 1998 to December 2003 were reviewed in present study. Patients with a history of previous orthodontic treatment, jaw surgery, facial trauma or systemic diseases which could potentially involve temporomandibular joint were excluded. The detection rate of TMJOA was calculated and its association with the possible risk factors of age, gender and malocclusion classifications was analyzed using the method of chi-square and multivariate logistic regression analysis. The clinical and radiographic characteristics were investigated and the radiographic findings before and after treatment were compared to evaluate the orthodontic effect on the articular bony structures.
Results: The detection rate of TMJOA in 10,032 patients before orthodontic treatment was 1.6% (159/10,032) and significantly higher in females (1.9%, 124/6,409) than in males(1.0%, 35/3,623)(chi-square = 13.925, P < 0.01).The detection rate increased positively with age (chi-square = 136.381, P < 0.01). Multivariate logistic regression analysis showed that patients with Angle II malocclusion were 1.683 times more likely to suffer from TMJOA compared with patients with Angle I malocclusion(Wald chi-square = 9.007, OR = 1.683, P < 0.01), while there was no significantly difference between the patients with Angle III and I malocclusion. Among the 85 TMJOA patients who finished their orthodontic treatments, 63 patients (74.1%, 63/85) maintained stable articular bony structure and the remaining 9(10.6%, 9/85) and 13 (15.3%, 13/85) patients showed recovering and deteriorating signs respectively according to the radiographs.
Conclusion: The detection rate of TMJOA associated with age, gender and malocclusion classifications. Stable articular bony structure was maintained in the majority of the TMJOA patients (74.1%, 63/85) during the orthodontic treatments.
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Phytochem Anal
December 2024
Institute of Oncology, the First Clinical Medical College, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Objectives: We used ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS), bioinformatics, and in vivo experiments to study the anti-colorectal cancer (CRC) effects of Wenzi Jiedu Decoction (WJD).
Methods: Detected the main components of WJD by UPLC-MS/MS. Obtained WJD targets and CRC targets through the open source database.
Sleep
December 2024
Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Study Objectives: Isolated REM sleep behavior disorder (iRBD) is recognized as a prodromal stage of alpha-synucleinopathies. Predicting phenoconversion in iRBD patients remains a key challenge. We aimed to investigate whether event-related potentials (ERPs) recorded during visuospatial attention task can serve as predictors of phenoconversion in iRBD patients.
View Article and Find Full Text PDFThorac Cancer
December 2024
Breast Disease Center, Peking University People's Hospital, Beijing, China.
Background: Sentinel lymph node biopsy (SLNB) using radioisotope tracer plus blue dye is the gold standard after neoadjuvant chemotherapy (NAC) in initially cN1 breast cancer patients, but clinical use still has limitations. This study aims to examine diagnostic performance of dual indocyanine green (ICG) and methylene blue tracing for SLNB in patients who have completed NAC for breast cancer with initially cN1 disease.
Methods: Adult women (20-80 years of age) scheduled to undergo NAC for biopsy-proven cT0-3N1M0 primary invasive breast cancer were consecutively enrolled in this prospective, multicenter, cohort study.
BMC Infect Dis
December 2024
Xi'an Chest Hospital, Xi'an, Shaanxi Province, China.
Objectives: This study evaluates the effectiveness of nanopore sequencing for accurate detection of Mycobacterium tuberculosis pathogens and drug resistance mutations in clinical specimens.
Methods: A retrospective analysis of 2,421 specimens from suspected tuberculosis patients admitted to Xi'an Chest Hospital from 2022 to 2023 was conducted, with 131 specimens undergoing via real-time, fluorescence-based quantitative Polymerase Chain Reaction (qPCR), simultaneous amplification and testing RNA (RNA), Mycobacterium culture, Mycobacterium smear, and nanopore sequencing. Employing clinical tuberculosis diagnoses as the gold standard, sensitivity, specificity, positive predictive value, negative predictive value, concordance rate, and Kappa coefficient were measured for the five detection techniques.
BMC Cancer
December 2024
Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, P. R. China.
Background: This study aimed to investigate the potential utility of Epithelial-mesenchymal transition (EMT) signaling cell detection in the early diagnosis of cervical lesions.
Methods: Enrichment of cervical epithelial cells was carried out using a calibrated membrane with 8-μm diameter pores. RNA-in situ hybridization (RNA-ISH) was employed to detect and characterize EMT cells utilizing specific EMT markers.
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