Application of coupling reaction between lithiated toluamide and benzonitrile for the synthesis of phenolic benzo[c]phenanthridine alkaloid, oxyterihanine.

Nguyen Le Thanh Hue Thi My Van Suh-Hee Lee Hyun Jin Choi Kwang Youl Lee Bok Yun Kang Won-Jea Cho

Arch Pharm Res

College of Pharmacy, Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.

Published: January 2008

The total synthesis of the natural phenolic benzo[c]phenanthridine alkaloid, oxyterihanine, was accomplished via substituted 3-arylisoquinoline intermediate. The key reaction was a coupling between the o-toluamide 4 and the benzonitrile 5.

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http://dx.doi.org/10.1007/s12272-008-1112-y	DOI Listing

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