AI Article Synopsis
- After major abdominal surgery, the study examined how oxygen consumption and hemodynamics change once sedation with midazolam is stopped.
- Researchers evaluated 18 patients, measuring sedation depth, oxygen consumption, and heart rate over an hour after ending midazolam infusion.
- The results showed that while the depth of sedation decreased significantly, oxygen consumption and heart rate dynamics remained unchanged after the sedation withdrawal.
Article Abstract
Background: The change of oxygen consumption after withdrawal of sedation is controversial. We evaluated the changes of sedation depth, oxygen consumption and hemodynamics after withdrawal of midazolam sedation in the patients undergoing major abdominal surgery.
Methods: We evaluated 18 patients after major abdominal surgery. Midazolam was used for intravenous sedation after admission to the ICU. Midazolam was administered at a bolus dose of 0.1 mg kg(-1), followed by continuous infusion at 0.04 mg kg(-1) hr(-1), which was adjusted every 2 hrs to achieve a desired level of sedation of 4 on Ramsay sedation scale (RSS). After about 14 hours of sedation, we stopped the infusion of midazolam. From that time, we measured systolic and mean arterial pressure, heart rate, minute volume and oxygen consumption, and evaluated RSS every 5 minutes for 1 hour. We evaluated RSS as sedation depth, oxygen consumption index (V(O2)I) and rate pressure product (RPP=systolic arterial pressure x heart rate) as hemodynamic parameters.
Results: RSS significantly decreased gradually, but the other parameters including V(O2)I and RPP were unchanged.
Conclusions: After withdrawal of midazolam sedation in the patients undergoing major abdominal surgery, the sedation depth became lighter, but V(O2)I and RPP were unchanged.
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