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'iCycle-pBAO': Automated patient-specific beam-angle selection in proton therapy applied to oropharyngeal cancer.
Radiother Oncol
February 2025
Department of Radiotherapy, Erasmus MC Cancer Institute, Rotterdam University Medical Center, Rotterdam, the Netherlands.
Objective: This study aimed to develop a fully-automated patient tailored beam-angle optimisation approach for intensity-modulated proton therapy (IMPT). For oropharynx cancer patients, the dosimetric impact of increasing the number of fields from 4 to 12 was systematically assessed.
Approach: A total-beam-space heuristic was developed to simultaneously select optimal patient specific candidate beam directions, according to a cost-function that penalises dose to OARs involved in clinically used NTCPs.
Plasma-derived protein and imaging biomarkers distinguish disease severity in oculopharyngeal muscular dystrophy.
J Neuromuscul Dis
December 2024
Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Background: Oculopharyngeal muscular dystrophy (OPMD) is a rare, late-onset, slowly progressive neuromuscular disorder characterized by ptosis, dysphagia, and proximal limb weakness. Emerging clinical trials require rapidly accessible and sensitive biomarkers to evaluate OPMD disease progression and potential response to future treatments.
Objective: This cross-sectional study was designed to identify candidate circulating protein and imaging biomarkers of OPMD severity for future use in clinical trials.
Comparison of Partial Endoscopic vs Surgical Fundoplication after Hiatal Hernia Repair.
J Am Coll Surg
January 2025
Prisma Health Upstate Department of Surgery, Greenville, SC.
Background: The concomitant hiatal hernia repair with endoscopic fundoplication (c-TIF) is a novel anti-reflux procedure that addresses the hiatus and the gastro-esophageal flap valve for surgical candidates with GERD. We aim to compare the outcomes of a hiatal hernia repair with endoscopic fundoplication (TIF) vs surgical partial fundoplication (anterior and posterior) with regards to quality-of-life scores at 12 months after surgery.
Study Design: Following IRB approval, a prospectively maintained anti-reflux database was retrospectively reviewed to identify patients who underwent a c-TIF procedure or a surgical hiatal hernia repair with partial fundoplication.
Increased prevalence of dysphagia in patients with severe atopic dermatitis candidates to biological therapy: implications for diagnosis and management of T2-related disorders.
Clin Exp Dermatol
January 2025
Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.
Antireflux surgery - choosing the right candidate.
Expert Rev Gastroenterol Hepatol
January 2025
Department of Gastroenterology & Hepatology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Introduction: Surgical gastric fundoplication is an effective treatment option for gastroesophageal reflux disease. In contrast to acid suppression, fundoplication nearly abolishes all types of reflux, acid and nonacid. However, in some cases, lasting side effects of the procedure may overshadow its positive effects.
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