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The effect of repeated hot water immersion on vascular function, blood pressure and central haemodynamics in individuals with type 2 diabetes mellitus.
J Therm Biol
December 2024
School of Psychology, Sport and Health Science, Faculty of Science and Health, University of Portsmouth, UK; Diabetes and Endocrinology Department, Portsmouth Hospitals University NHS Trust, Portsmouth, UK. Electronic address:
Article Synopsis
- Type 2 diabetes mellitus (T2DM) can lead to problems with blood vessel function, increasing the risk of heart issues, and hot water immersion (HWI) might help improve this, though research is limited.
- A study with 14 participants assessed the effects of 8-10 sessions of HWI, measuring various heart and blood vessel functions before and after the treatment.
- Results showed significant reductions in cardiac index, stroke volume index, resting heart rate, and systolic blood pressure, suggesting HWI could benefit heart-related measures in T2DM, but it didn’t improve overall vascular function.
Consumption of plant sterols-enriched soy milk with a healthy dietary pattern diet lowers blood pressure in adults with metabolic syndrome: A randomized controlled trial.
Nutr Metab Cardiovasc Dis
January 2025
Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore. Electronic address:
Background & Aims: Plant sterols (PS) have been shown to lower blood lipid-lipoproteins concentrations and may serve as a potential functional ingredient for cardiovascular disease (CVD) risk management. However, there are limited studies examining this effect in individuals with metabolic syndrome (MetS). The aim of this study was to evaluate the effects of PS-enriched food consumption as part of a healthy dietary pattern (HDP) on blood pressure and endothelial function in Singaporean adults with MetS.
View Article and Find Full Text PDFChronic endothelial dopamine receptor stimulation improves endothelial function and hemodynamics in autosomal dominant polycystic kidney disease.
Kidney Int
December 2024
University Rouen Normandie, Institut national de la santé et de la recherche médicale (INSERM) U1096, Endothélium, Valvulopathies, Insuffisance cardiaque (EnVI), Rouen, France; Department of Pharmacology, Centre Hospitalier Universitaire (CHU) Rouen, Rouen, France; Centre d'Investigation CLinique-Centre de Ressources Biologiques (CIC-CRB) 1404, Rouen, France. Electronic address:
Article Synopsis
- The study explores how altered endothelial flow sensitivity related to polycystin deficiency contributes to hypertension in autosomal dominant polycystic kidney disease (ADPKD) patients.
- Nineteen ADPKD patients were treated with the dopamine receptor agonist rotigotine, showing that a higher dose significantly improved nitric oxide release and endothelial function without major changes in overall blood pressure.
- The findings suggest that targeting endothelial dopamine receptors could be a promising new treatment strategy to mitigate cardiovascular issues linked with ADPKD.
The acute effects of dietary nitrate supplementation on postmenopausal endothelial resistance to ischemia reperfusion injury: a randomized, placebo-controlled, double blind, crossover clinical trial.
Can J Physiol Pharmacol
November 2024
Integrative and Biomedical Physiology, The Pennsylvania State University, University Park, PA, USA.
Article Synopsis
- Postmenopausal cardiovascular health is crucial for longevity, and beetroot juice (BR), which is rich in nitrates, can enhance nitric oxide levels, benefiting endothelial function.
- Research compared the effects of a single dose of nitrate-rich beetroot juice on early-postmenopausal women to late-postmenopausal women, finding different improvements in endothelial function and resistance to ischemia-reperfusion (IR) injury.
- The study showed that while beetroot juice significantly improved macrovascular function in late-postmenopausal women, early-postmenopausal women had a stronger overall response, indicating that menopause timing may influence how dietary nitrates affect cardiovascular health.
Impact of Insulin-Induced Relative Hypoglycemia on Vascular Insulin Sensitivity and Central Hemodynamics in Prediabetes.
J Clin Endocrinol Metab
March 2024
Department of Kinesiology and Health, Rutgers University, New Brunswick, NJ.
Context: Relative hypoglycemia (RH) is linked to sympathetic responses that can alter vascular function in individuals with type 2 diabetes. However, less is known about the role of RH on hemodynamics or metabolic insulin sensitivity in prediabetes.
Objective: Determine if RH alters peripheral endothelial function or central hemodynamics to a greater extent in those with prediabetes (PD) versus normoglycemia (NG).
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