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Neurobiological Correlates of Rheumatoid Arthritis and Osteoarthritis: Remodelling and Plasticity of Nociceptive and Autonomic Innervations in Synovial Joints.
Neuroscientist
December 2024
Faculty of Engineering and Science, University of Greenwich London, Chatham Maritime, Kent, UK.
Swelling, stiffness, and pain in synovial joints are primary hallmarks of osteoarthritis and rheumatoid arthritis. Hyperactivity of nociceptors and excessive release of inflammatory factors and pain mediators play a crucial role, with emerging data suggesting extensive remodelling and plasticity of joint innervations. Herein, we review structural, functional, and molecular alterations in sensory and autonomic axons wiring arthritic joints and revisit mechanisms implicated in the sensitization of nociceptors, leading to chronic pain.
View Article and Find Full Text PDFSilent otitis media with multiple intracranial complications.
BMJ Case Rep
December 2024
Department of Otorhinolaryngology, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth- Deemed to be-University, Pondicherry, India.
Article Synopsis
- A 40-year-old man with no prior health issues presented with a 5-day history of swelling behind his right ear, along with a previous episode of ear pain two months earlier.
- Examination and imaging revealed right otomastoiditis, which is an infection of the mastoid bone, along with serious complications like a bony defect and brain abscesses.
- After starting intravenous antibiotics and undergoing surgery to drain the abscess, he had a cortical mastoidectomy three weeks later and has had no further health complaints during regular follow-ups over the past six months.
Case report: Unveiling the silent threat in the ICU - a case of disseminated invasive aspergillosis in a patient with fulminant myocarditis.
Front Immunol
December 2024
Fourth Department of Critical Care Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China.
Invasive aspergillosis (IA) significantly increases mortality in critically ill patients in the ICU and its occurrence is closely related to immunocompromise. Dissemination of IA is easily misdiagnosed and mistreated due to its ability to invade multiple systems throughout the body and lack of typical clinical manifestations. In this case, a 25-year-old previously healthy woman was hospitalized with fulminant myocarditis and treated with veno-arterial extracorporeal membrane pulmonary oxygenation (VA-ECMO) support and intravenous acyclovir, high-dose methylprednisolone, and immunoglobulin.
View Article and Find Full Text PDFRisk factors for delirium occurring after deep brain stimulation surgery in patients with Parkinson's disease.
Acta Neurochir (Wien)
November 2024
Department of Neurosurgery, Memorial Sisli Hospital, Istanbul, Turkey.
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- * Out of 83 reviewed patients, 6% developed delirium, with significant associations found for older age, longer disease duration, and higher preoperative cerebral atrophy rates.
- * Age over 68 and a disease duration of 11 years or more were identified as independent risk factors for developing post-DBS delirium.
A Silent Intruder: Unveiling a Schwannoma in the Distal Forearm.
Cureus
October 2024
Orthopedics and Traumatology, Hospital Canselor Tuanku Muhriz UKM, Kuala Lumpur, MYS.
Schwannomas are rare, benign tumors that develop from Schwann cells in the peripheral nervous system, and they make up only a small fraction of cases found in the upper limbs. Oftentimes, these tumors do not show symptoms until they start pressing on nearby structures. In this case report, we share the case of a 34-year-old woman who had painless swelling in her right distal forearm for three years.
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