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Normal tissue complication probability model predicting taste impairment in head and neck cancer patients: Evaluating the taste bud bearing tongue mucosa as a predictor.
Radiother Oncol
January 2025
Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:
Background/purpose: Taste impairment is a common yet complex toxicity of head and neck cancer (HNC) radiotherapy treatment that may affect quality of life of survivors. This study aimed to predict acute and late taste impairment using taste bud bearing tongue mucosa as a new taste-specific organ-at-risk compared to full oral cavity as identified in previous studies.
Materials/methods: Included HNC patients were treated with curative radiotherapy between 2007 and 2022.
Food hardness preference reveals multisensory contributions of fly larval gustatory organs in behaviour and physiology.
PLoS Biol
January 2025
Department of Biology, University of Fribourg, Fribourg, Switzerland.
Article Synopsis
- Food is a multisensory experience, relying on visuals, taste, smell, and, surprisingly, texture to assess nutritional value and safety.
- Despite being overlooked, texture offers crucial information about food's physical properties, like hardness and liquidity.
- Recent findings show that some sensory neurons are not limited to specific stimuli; instead, they can respond broadly, indicating greater sensory complexity than previously thought.
SARS-CoV-2 infection in microglia and its sequelae: What do we know so far?
Brain Behav Immun Health
December 2024
James & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic. After the success of therapeutics and worldwide vaccination, the long-term sequelae of SARS-CoV-2 infections are yet to be determined. Common symptoms of COVID-19 include the loss of taste and smell, suggesting SARS-CoV-2 infection has a potentially detrimental effect on neurons within the olfactory/taste pathways, with direct access to the central nervous system (CNS).
View Article and Find Full Text PDF[Neurological evaluation of "post-COVID-19 syndrome" (PCS)].
Fortschr Neurol Psychiatr
January 2025
Institut für neurorehabilitative Forschung (InFo), Assoziiertes Institut der Medizinischen Hochschule Hannover (MHH), BDH-Klinik Hess. Oldendorf gGmbH, Hessisch Oldendorf, Germany.
The so-called "post-COVID-19 syndrome" (PCS) includes a variety of subjective complaints and represents a challenge to medical evaluation. The review focuses on symptom validation of the most common neurological, neuropsychiatric and neuropsychological PCS symptoms like fatigue, loss of smell and taste, problems speaking or communicating, cognitive disorders, dysaesthesia and persistent muscle pain.
View Article and Find Full Text PDFOtolaryngological manifestations of cystic fibrosis in children: A systematic review.
Int J Pediatr Otorhinolaryngol
January 2025
Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgium; Department of Translational Neuroscience, Faculty of Medicine and Health Science, University of Antwerp, Antwerp, Belgium. Electronic address:
Purpose: Cystic fibrosis (CF) is the most common autosomal recessive disorder in the Caucasian population. Otolaryngological manifestations pose a significant impact on the quality of life of children with CF. The primary aim of this review is to provide a state of the art update of current literature on the otolaryngological manifestations of CF in children.
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