AI Article Synopsis
- The study investigates the expression of senescence-associated genes in skin biopsies from both young and old human donors to understand intrinsic skin aging.
- Key findings include the up-regulation of TGF-beta1 and its related genes, as well as antioxidant enzymes in the dermis of older individuals, indicating their potential role in intrinsic aging.
- The research highlights the importance of differentiating between intrinsic and extrinsic aging in future studies by using whole transcriptome analyses.
Article Abstract
It is often described that it is difficult to really discriminate the cause of intrinsic skin aging. The aim of this study was to compare the profiles of expression of senescence-associated genes in biopsies of dermis from young and old human donors. TGF-beta1 was up-regulated in the dermis of old donors as well as the TGF-beta1-regulated genes. The anti-oxidant enzymes Selenium-dependent Glutathione peroxidase and Glutatione S-Transferase Theta 1 were also up-regulated in old dermis as well as Tumor Necrosis Factor Receptor Superfamily 1A. None of these genes had altered expression level in skin fibroblasts embedded in a collagen matrix and exposed to sublethal doses of UVB, suggesting their involvement in intrinsic aging. This study represents a proof-of-concept of larger whole transcriptome studies where all avenues should be used to subtract changes in gene expression due to extrinsic aging from changes potentially due to intrinsic aging.
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| http://dx.doi.org/10.1007/s10522-008-9127-9 | DOI Listing |
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