Multifocal variant of heterotopic ossification.

Br J Radiol

Department of Radiology, University of South Alabama, 2451 Fillingham Street, Mobile, Alabama 36617, USA.

Published: March 2008

In this case report, we present a 25 year follow-up of a single patient with a previously undescribed multifocal variant of heterotopic ossification. The patient presented with multiple occurrences of lesions similar to myositis ossificans atraumatica as well as some lesions resembling exostoses/osteochondromas. Several images and histological sections show the range of appearances and locations of her somewhat disparate lesions, including an exostosis with intraspinal extension. Until additional similar cases are brought forward, we consider this a unique variant of heterotopic ossification. The precise aetiology of this patient's condition is unknown.

Download full-text PDF

Source
http://dx.doi.org/10.1259/bjr/98436750DOI Listing

Publication Analysis

Top Keywords

variant heterotopic
12
heterotopic ossification
12
multifocal variant
8
ossification case
4
case report
4
report year
4
year follow-up
4
follow-up single
4
single patient
4
patient undescribed
4

Similar Publications

The posterior petroclinoid fold and petroclival ligament ossification patterns.

Surg Radiol Anat

January 2025

Department of Anatomy, School of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, 75 Mikras Asias str, Goudi, Athens, 11527, Greece.

Background: The skull base ligaments have been extensively studied in the literature due to their clinical and surgical significance. The posterior petroclinoid fold (PPCNF) and petroclival ligament (PCVL) are two adjacent structures that have barely been studied and are frequently confused. The present study uses an innovative classification system to investigate the PPCNF and PCVL ossification patterns.

View Article and Find Full Text PDF

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare disorder caused by heterozygous pathogenic variants and is characterized by both progressive heterotopic ossification of the soft tissues and congenital malformations of the great toe. In addition to pathological skeletal metamorphosis, patients with FOP experience diverse neurological symptoms such as chronic pain and involuntary movements; however, little is known about the association between FOP and epileptic seizures. We report the case of a young boy with FOP who sustained multiple major fractures due to epileptic loss of consciousness.

View Article and Find Full Text PDF

Background: The protective impact of the Critical View of Safety (CVS) approach on the vasculo-biliary injuries during laparoscopic cholecystectomy (LC) depends largely upon the understanding of the normal and variant anatomy. Structures exposed during the acquisition of the CVS can deviate from the typical dual configuration of the cystic duct and artery (gallbladder pedicle) representing either a third (supernumerary) or atypical in course (heterotopic) element. The aim of this study was to determine the identity and the frequency of these anatomical elements and to propose anatomic schemata that can guide the achievement of CVS by surgeons.

View Article and Find Full Text PDF

An important complication of prolonged support of the left ventricle with an assist device when implanted in patients with heart failure is unloading-induced cardiac atrophy. Our recent study suggested that sex-linked differences in the development of atrophy induced by heterotopic heart transplantation (HTX) do exist, however, the role of the environmental conditions dependent on plasma concentrations of sex hormones remains elusive. We aimed to compare the course of HTX-induced cardiac atrophy in male and female rats after gonadectomy with substitution of steroid hormones of the opposite sex.

View Article and Find Full Text PDF

Genotype-Phenotype Correlation of GNAS Gene: Review and Disease Management of a Hotspot Mutation.

Int J Mol Sci

October 2024

Medical and Laboratory Genetics Unit, A.O.R.N. "Antonio Cardarelli", 80131 Naples, Italy.

Article Synopsis
  • Defects in a specific gene are primarily linked to pseudohypoparathyroidism Ia (PHP1a), with various mutation types identified across all 13 exons.
  • A noteworthy mutation, a 4 bp deletion c.565_568delGACT, is recognized as a mutation hotspot, though focused studies on this variant have been limited.
  • The authors reported two PHP1a cases related to this deletion and found that patients with the c.565_568delGACT mutation exhibited a higher prevalence of certain characteristics—like brachydactyly and intellectual disability—compared to those with other mutations, suggesting a need for tailored patient monitoring.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!