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In a review of 29 cases of solitary and multicentric hemangioendothelial sarcomas of bone, 14 were found to have histologic features of epithelioid hemangioendotheliomas. These were characterized by the presence of epithelioid or "histiocytoid" endothelial cells that were either round or spindle-shaped. Intracytoplasmic vacuolization was noted, and some showed nesting of cells, mimicking metastatic adenocarcinoma.

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A case of an angioglomoid tumour of bone occurring in the mandible is presented. The lesion is characterized by epithelioid and endothelioid cells that exhibit single and multilayered rings with a central signet ring-like cell suggesting vascular differentiation. These cells are arranged in strands and nests that are dispersed in a myxoid stroma.

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