This paper discusses the use of evolutionary programming (EP) for computer-aided design and testing of neural controllers applied to problems in which the system to be controlled is highly uncertain. Examples include closed-loop control of drug infusion and integrated control of HVAC/lighting/utility systems in large multi-use buildings. The method is described in detail and applied to a modified Cerebellar Model Arithmetic Computer (CMAC) neural network regulator for systems with unknown time delays. The design and testing problem is viewed as a game, in that the controller is chosen with a minimax criterion i.e., minimize the loss associated with its use on the worst possible plant. The technique permits analysis of neural strategies against a set of feasible plants. This yields both the best choice of control parameters and identification of that plant which is most difficult for the best controller to handle.
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http://dx.doi.org/10.1109/72.265962 | DOI Listing |
MicroPubl Biol
February 2025
HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States.
Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant disease that interferes with the formation of arteries. The gene encodes for the protein endoglin which is used to properly develop and remodel arteries. The removal of endoglin forms telangiectasias that cause bleeding from the nose and vital organs.
View Article and Find Full Text PDFPhilos Trans A Math Phys Eng Sci
March 2025
Department of Pediatrics, Stanford University, Stanford, CA, USA.
Bayesian boundary condition (BC) calibration approaches from clinical measurements have successfully quantified inherent uncertainties in cardiovascular fluid dynamics simulations. However, estimating the posterior distribution for all BC parameters in three-dimensional (3D) simulations has been unattainable due to infeasible computational demand. We propose an efficient method to identify Windkessel parameter posteriors: We only evaluate the 3D model once for an initial choice of BCs and use the result to create a highly accurate zero-dimensional (0D) surrogate.
View Article and Find Full Text PDFInt J Numer Method Biomed Eng
March 2025
Department of Mathematics, Università degli Studi di Trento, Trento, Italy.
Research in the dynamics of blood flow is essential to the understanding of one of the major driving forces of human physiology. The hemodynamic conditions experienced within the cardiovascular system generate a highly variable mechanical environment that propels its function. Modeling this system is a challenging problem that must be addressed at the systemic scale to gain insight into the interplay between the different time and spatial scales of cardiovascular physiology processes.
View Article and Find Full Text PDFHealthcare (Basel)
February 2025
Centre for Health Services Research, University of Queensland, Herston 4006, Australia.
: Resource trade-offs are a universal feature of decision-making in healthcare. Public funding for home care is an example of a complex resource allocation decision, requiring balance between the needs of the individual and the capacity of the welfare system to meet those needs across the population. Under consumer-directed care policies, responsibility for resource allocation decisions rests with the care recipient, but there is no existing measure of allocative efficiency resulting from these consumer-led decisions.
View Article and Find Full Text PDFJ Genet Eng Biotechnol
March 2025
Departement of Clinical and Chemical Pathology, Kasr Alainy Medical School, Cairo University, Egypt.
Background: The emergence of worldwide pandemic caused by coronavirus 2 (SARS-CoV-2) has caused a radical change in everyday life. Patients diseased with FMF show manifestations and labs highly similar to COVID infected patients. In the current study, we evaluate the presence of variants in exon 10 of MEFV gene and the relation with severity of symptoms in patients with COVID-19 pneumonia.
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