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Wavebreakers in excitable systems and possible applications for corrosion mitigation.
Chaos
January 2025
Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, USA.
Traveling waves of excitation arise from the spatial coupling of local nonlinear events by transport processes. In corrosion systems, these electro-dissolution waves relay local perturbations across large portions of the metal surface, significantly amplifying overall damage. For the example of the magnesium alloy AZ31B exposed to sodium chloride solution, we report experimental results suggesting the existence of a vulnerable zone in the wake of corrosion waves where local perturbations can induce a unidirectional wave pulse or segment.
View Article and Find Full Text PDFSynthesis and Evaluation of a Bifunctional Chelator for Thorium-227 Targeted Radiotherapy.
J Med Chem
January 2025
Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Thorium-227 (Th) is an α-emitting radionuclide currently under investigation for targeted alpha therapy. Available chelators used for this isotope suffer from challenging multistep syntheses. Here, we present the synthesis and preclinical evaluation of a novel bifunctional chelator, SCN-Bn-DOTHOPO, which contains an isothiocyanate group that is suitable for conjugation to biological molecules.
View Article and Find Full Text PDFEfficient Expression and Activity Optimization of Manganese Peroxidase for the Simultaneous Degradation of Aflatoxins AFB, AFB, AFG, and AFG.
J Agric Food Chem
January 2025
School of Food Science and Technology, International Joint Laboratory on Food Safety, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China.
Aflatoxins (AFs), notorious mycotoxins that pose significant risks to human and animal health, make biodegradation extremely crucial as they offer a promising approach to managing and reducing their harmful impacts. In this study, we identified a manganese peroxidase from (Mnp) through protein similarity analysis, which has the capability to degrade four AFs (AFB, AFB, AFG, and AFG) simultaneously. The gene encoding this enzyme was subject to codon optimization, followed by cold shock induction expression using the pColdII vector, leading to the soluble expression of manganese peroxidase (Mnp) in .
View Article and Find Full Text PDFOptimizing Pyrazinamide Use: A Low-Hanging Fruit in Improving Outcomes with Tuberculous Meningitis? Narrative Review.
Infect Dis Ther
January 2025
Christian Medical College, Vellore, Tamil Nadu, India.
Tuberculous meningitis (TBM) disables more than a third of its sufferers. Recent research has focused on optimizing the antitubercular regimen, mainly by increasing the dosage of rifampicin. However, pyrazinamide, with higher penetration into the central nervous system, is generally overlooked.
View Article and Find Full Text PDFUltrasound radiomics predict the success of US-guided percutaneous irrigation for shoulder calcific tendinopathy.
Jpn J Radiol
January 2025
Artificial Intelligence and Translational Imaging (ATI) Lab, Department of Radiology, School of Medicine, University of Crete, Voutes Campus, Heraklion, Greece.
Objective: Calcific tendinopathy, predominantly affecting rotator cuff tendons, leads to significant pain and tendon degeneration. Although US-guided percutaneous irrigation (US-PICT) is an effective treatment for this condition, prediction of patient' s response and long-term outcomes remains a challenge. This study introduces a novel radiomics-based model to forecast patient outcomes, addressing a gap in the current predictive methodologies.
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