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Mechanistic Aspects of the Photophysics of UVA Filters Based on Meldrum Derivatives.
J Phys Chem A
July 2021
Aix Marseille Université, CNRS, ICR, Av. Esc. Normandie-Niemen BJ5-D22, Marseille 13397, France.
Skin photoprotection against UVA radiation is crucial, but it is hindered by the sparsity of approved commercial UVA filters. Sinapoyl malate (SM) derivatives are promising candidates for a new class of UVA filters. They have been previously identified as an efficient photoprotective sunscreen in plants due to their fast nonradiative energy dissipation.
View Article and Find Full Text PDFBooster Effect of a Natural Extract of (Fernblock®) That Improves the UV Barrier Function and Immune Protection Capability of Sunscreen Formulations.
Front Med (Lausanne)
June 2021
Department of Medicine and Medical Specialties, Alcalá de Henares University, Madrid, Spain.
Novel approaches to photoprotection must go beyond classical MED measurements, as discoveries on the effect of UV radiation on skin paints a more complex and multi-pronged scenario with multitude of skin cell types involved. Of these, photoimmunoprotection emerges as a crucial factor that protects against skin cancer and photoaging. A novel immune parameter is enabled by the precise knowledge of the wavelength and dose of solar radiation that induces photoimmunosupression.
View Article and Find Full Text PDFFunctional photostability and cutaneous compatibility of bioactive UVA sun care products.
J Photochem Photobiol B
July 2015
Department of Pharmacy, University of São Paulo, 580 Prof. Lineu Prestes Av., Bl. 15, Conjunto das Químicas, Cidade Universitária, 05508-900 São Paulo, SP, Brazil.
Sunscreens are the most-established approach for photoprotection. The strategy of providing antioxidant properties to sun care products by addition of natural and potent anti-free radical compounds has led to the development of bioactive sunscreens, able to neutralize the harmful effects of ultraviolet (UV) radiation. UVA filters, such as benzophenone-3 (BP) and butyl methoxydibenzoylmethane (BMDBM), can exhibit photodegradation which limits the development of broad spectrum sunscreens.
View Article and Find Full Text PDFBroad-spectrum moisturizer effectively prevents molecular reactions to UVA radiation.
Cutis
December 2012
La Roche-Posay Pharmaceutical Laboratories, Asnières, France.
The damaging effects of UVA radiation have been well-documented. UVA radiation is known to induce molecular, cellular, and clinical damage. Such harm may lead to photoaging, immune system depression, altered gene expression, or oncogene and tumor suppressor gene modulation, all of which are partly responsible for the development of skin cancer.
View Article and Find Full Text PDFThe development of efficient sunscreens.
Indian J Dermatol Venereol Leprol
June 2012
L'Oréal Research and Innovation, France.
Skin exposure to acute or repetitive ultraviolet light induces risks which are now well identified. An efficient photoprotection is thus required for both UVB and UVA radiation. In particular, increasing evidence of the detrimental effects of UVA on skin has led to the development of a new generation of sunscreens that provide effective protection throughout the whole UV radiation spectrum.
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