Increase in spermine content coordinated with siderophore production in Paracoccus denitrificans.

J Bacteriol

Department of Medicinal Chemistry, J. Hillis Miller Health Science Center, University of Florida, Gainesville 32610-0485.

Published: April 1991

Spermine is present in relatively low amounts in Paracoccus denitrificans cultured aerobically in an ammonium succinate minimal salts medium supplemented with 50 microM iron(III). However, in iron-deprived cultures [minimal salts medium containing 0.5 microM iron(III)], spermine content increases by an order of magnitude in coordination with the well-known responses to iron derivation, e.g., derepression of siderophore synthesis and siderophore excretion. When iron-deprived cultures exhibiting both high spermine content and strong siderophore production are reseeded into fresh minimal salts medium containing 50 microM iron[III], both siderophore production and spermine content fall rapidly. Five hours after iron supplementation, spermine is below limits of detection. These results suggest a specific role for spermine in the response of P. denitrificans to low-iron stress.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC207773PMC
http://dx.doi.org/10.1128/jb.173.7.2238-2243.1991DOI Listing

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