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Tailoring Design of Microneedles for Drug Delivery and Biosensing.
Mol Pharm
January 2025
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Microneedles (MNs) are emerging as versatile tools for both therapeutic drug delivery and diagnostic monitoring. Unlike hypodermic needles, MNs achieve these applications with minimal or no pain and customizable designs, making them suitable for personalized medicine. Understanding the key design parameters and the challenges during contact with biofluids is crucial to optimizing their use across applications.
View Article and Find Full Text PDFAntibody dynamics in dogs submitted to different canine visceral leishmaniasis treatment protocols.
Rev Bras Parasitol Vet
January 2025
Programa de Pós-graduação em Medicina Veterinária, Laboratório de Doenças Parasitárias, Departamento de Medicina Veterinária Preventiva, Universidade Federal de Santa Maria - UFSM, Santa Maria, RS, Brasil.
This study evaluated dynamics of antibodies in dogs treated for canine visceral leishmaniasis (CVL). Twenty-one dogs naturally infected by Leishmania spp. were grouped based on the treatment protocol: G1 (n=4) received allopurinol; G2 (n=10) allopurinol with miltefosine; and G3 (n=7) allopurinol, miltefosine and Leish-Tec® vaccine.
View Article and Find Full Text PDFChanges in enzymatic activity and oxidative stress in honeybees kept in the apiary and laboratory conditions during the course of nosemosis.
PLoS One
January 2025
Department of Immunobiology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Lublin, Poland.
The aim of this study was to investigate the changes in the level of oxidative stress and lysozyme-like and phenoloxidase (PO) activity under the influence of nosemosis. Honeybees were kept in natural (apiary) and artificial (laboratory) conditions. In this study, it was shown for the first time that honeybees kept in apiaries have higher levels and activity of the studied parameters than honeybees kept in the laboratory.
View Article and Find Full Text PDFActive Disturbance Rejection Control for an automotive suspension system based on parameter tuning using a fuzzy technique.
PLoS One
January 2025
Faculty of Mechanical Engineering, Thuyloi University, Hanoi, Vietnam.
Road surface roughness is the cause of vehicle vibration, which is considered a system disturbance. Previous studies on suspension system control often ignore the influence of disturbances while designing the controller, leading to system performance degradation under severe vibration conditions. In this work, we propose a control method to improve active suspension performance that reduces vehicle vibration by eliminating the influence of road disturbances.
View Article and Find Full Text PDFImproving rupture status prediction for intracranial aneurysms using wall shear stress informatics.
Acta Neurochir (Wien)
January 2025
Department of Neurosurgery, College of Medicine, University of Michigan, Ann Arbor, MI, USA.
Background: Wall shear stress (WSS) plays a crucial role in the natural history of intracranial aneurysms (IA). However, spatial variations among WSS have rarely been utilized to correlate with IAs' natural history. This study aims to establish the feasibility of using spatial patterns of WSS data to predict IAs' rupture status (i.
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