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| http://dx.doi.org/10.1038/embor.2008.13 | DOI Listing |
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Compromising tyrosine hydroxylase function extends and blunts the temporal profile of reinforcement by dopamine neurons in .
J Neurosci
January 2025
Leibniz Institute for Neurobiology (LIN), Department of Genetics of Learning and Memory, Magdeburg, 39118 Germany
For a proper representation of the causal structure of the world, it is adaptive to consider both evidence for and evidence against causality. To take punishment as an example, the causality of a stimulus is unlikely if there is a temporal gap before punishment is received, but causality is credible if the stimulus immediately precedes punishment. In contrast, causality can be ruled out if the punishment occurred first.
View Article and Find Full Text PDFTransLeish: Identification of membrane transporters essential for survival of intracellular Leishmania parasites in a systematic gene deletion screen.
Nat Commun
January 2025
School of Infection and Immunity, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA, UK.
For the protozoan parasite Leishmania, completion of its life cycle requires sequential adaptation of cellular physiology and nutrient scavenging mechanisms to the different environments of a sand fly alimentary tract and the acidic mammalian host cell phagolysosome. Transmembrane transporters are the gatekeepers of intracellular environments, controlling the flux of solutes and ions across membranes. To discover which transporters are vital for survival as intracellular amastigote forms, we carried out a systematic loss-of-function screen of the L.
View Article and Find Full Text PDFFrom Mammals to Insects: Exploring the Genetic and Neural Basis of Eating Behavior.
Annu Rev Genet
November 2024
Department of Neurobiology and Behavior, Cornell University, Ithaca, New York, USA; email:
Article Synopsis
- Obesity and anorexia are severe health issues with complex genetic and neuronal factors that disrupt eating behaviors, leading to dangerous weight changes.
- Despite existing treatment options, they often have limited effectiveness, highlighting the need for more advanced understanding and strategies.
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BIFROST: A method for registering diverse imaging datasets of the brain.
Proc Natl Acad Sci U S A
November 2024
Department of Neurobiology, Stanford University, Stanford, CA 94305.
Imaging methods that span both functional measures in living tissue and anatomical measures in fixed tissue have played critical roles in advancing our understanding of the brain. However, making direct comparisons between different imaging modalities, particularly spanning living and fixed tissue, has remained challenging. For example, comparing brain-wide neural dynamics across experiments and aligning such data to anatomical resources, such as gene expression patterns or connectomes, requires precise alignment to a common set of anatomical coordinates.
View Article and Find Full Text PDFDifferential regulation of sleep by blue, green, and red light in .
Front Behav Neurosci
October 2024
Neuroscience Program, Skidmore College, Saratoga Springs, NY, United States.
Introduction: Exposure to blue-enriched light from electronic devices is an emergent disruptor of human sleep, especially at particular times of day. Further dissection of this phenomenon necessitates modeling in a tractable model organism.
Methods: Thus, we investigated the effects of light color on sleep in .
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