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Sex hormone-dependent host-microbiome interactions and cardiovascular risk (XCVD): design of a longitudinal multi-omics cohort study.
BMJ Open
January 2025
Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Introduction: Cardiovascular diseases (CVDs) present differently in women and men, influenced by host-microbiome interactions. The roles of sex hormones in CVD outcomes and gut microbiome in modifying these effects are poorly understood. The XCVD study examines gut microbiome mediation of sex hormone effects on CVD risk markers by observing transgender participants undergoing gender-affirming hormone therapy (GAHT), with findings expected to extrapolate to cisgender populations.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.
Background: Increased stress, a proposed risk factor for Alzheimer's disease (AD), is associated with increased brain and cognitive vulnerabilities in older populations, which may be different in women and men.
Objective: To examine cross-sectional associations between circulating stress hormones (epinephrine, norepinephrine, cortisol, dehydroepiandrosterone sulfate (DHEAS), and DHEAS/cortisol ratio) and multimodal measures of brain health and cognition sensitive to AD.
Method: 132 cognitively unimpaired older participants without clinical depression (age = 74.
Background: Alzheimer's Disease (AD) is a complex neurodegenerative disease characterized by multiple etiologies that remains without a cure. Diabetes, dyslipidemia, hypertension, and inflammation are well-known risk factors for AD, and FDA-approved therapeutics for these conditions have been associated with a reduced risk of developing AD. This study aims to evaluate the impact of diabetes medications (DBMD), lipid-lowering (LIPL), antihypertensive (AHTN), and non-steroidal anti-inflammatory (NSD) therapeutics, alone or combined, on cognitive performance in an AD population.
View Article and Find Full Text PDFMusculoskeletal complaints among gastrointestinal endoscopists: prevalence, risk factors, and occupational impact. Insights from a Spanish national survey.
Rev Esp Enferm Dig
January 2025
Gastroenterology , Hospital Álvaro Cunqueiro, España.
Background: The absence of proper ergonomics in digestive endoscopy, combined with an increasing workload, has contributed to a growing incidence of musculoskeletal complaints among endoscopists. This study aims to assess the frequency of musculoskeletal complaints and their impact on clinical practice among Spanish endoscopists.
Methods: An electronic survey was sent to active members of the Spanish Society of Digestive Endoscopy (SEED) in July 2019.
Background: Low levels of high density lipoprotein cholesterol (HDL-c) are a risk factors for atherosclerotic cardiovascular disease (ASCVD). ASCVD can increase the risk for dementia. However, the link between HDL-C and incidence of dementia remain less clear specifically in women.
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