3-(Tridecafluoroundecyl)catechol (8) and 3-(nonafluoropentadecyl)catechol (9), perfluorinated analogues of pentadecylcatechol (PDC), a constituent of poison ivy, have been synthesized. These compounds were nonsensitizers in mice. Compounds 8 and 9, however, were elicitors of allergic contact dermatitis in PDC-sensitized animals. Moreover, compound 9 exhibited tolerogenic properties to sensitization by poison ivy allergens, i.e. mice pretreated with perfluorinated compounds could not be sensitized to PDC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jm00107a022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The poison ivy does not normally occur in Slovakia, like in the Czech Republic, but it can be introduced. The venom of the black widow spider is an effective weapon for capturing prey. It is a mixture of various active substances containing a protein neurotoxin called α-latrotoxin (α-LTX).
View Article and Find Full Text PDFMultiple Omics Analyses Reveal Activation of Nitrogen Metabolism and Flavonoid Glycosylation in Under High Temperature.
Biology (Basel)
October 2024
Shaanxi Engineering Research Centre for Conservation and Utilization of Botanical Resources, Xi'an Botanical Garden of Shaanxi Province, Institute of Botany of Shaanxi Province, Xi'an 710061, China.
Article Synopsis
- Lacquer trees, which are important for the economy, face stress from high summer temperatures, prompting a study of their responses using transcriptomic, proteomic, and metabolomic analyses.
- The research discovered significant changes in metabolites, with 224 being upregulated and 69 downregulated, alongside hormonal fluctuations where jasmonic acid increased while abscisic acid decreased.
- Key findings included the upregulation of specific genes linked to nitrogen transport and amino acid production, as well as 35 protein modules identified to be involved in secondary metabolite biosynthesis, indicating complex regulatory mechanisms at play.
A multiomics investigation into the evolution and specialized metabolisms of three Toxicodendron cultivars.
Plant J
December 2024
Key Laboratory for Forest Genetic and Tree Improvement and Propagation in Universities of Yunnan Province, Southwest Forestry University, Kunming, 650224, China.
Toxicodendron species are economically and medicinally important trees because of their rich sources of natural products. We present three chromosome-level genome assemblies of Toxicodendron vernicifluum 'Dali', Toxicodendron succedaneum 'Vietnam', and T. succedaneum 'Japan', which display diverse production capacities of specialized metabolites.
View Article and Find Full Text PDFTargeting insulin resistance: myricetin and isorhamnetin from , and luteolin from enhance glucose uptake and AMPK signaling in HepG2 cells.
Nat Prod Res
October 2024
Department of Biochemistry, Osmania University, Hyderabad, India.
This study examined five plants () for their potential to address insulin resistance in type 2 diabetes. assays showed that leaves and flowers inhibited α-glucosidase and α-amylase while enhancing glucose uptake in normal and insulin-resistant HepG2 cells. Phytochemical screening and SPE purification identified the key constituents responsible for the effects.
View Article and Find Full Text PDFTranscriptome and Metabolomic Analyses Reveal Tissue-Specific Glycosylation of Phenylpropanoids and Flavonoids in Toxicodendron vernicifluum.
Physiol Plant
September 2024
College of Forestry, Northwest A&F University, Yangling, Shaanxi, China.
Toxicodendron vernicifluum (Stokes) F. A. Barkley is a tree species used primarily for lacquer production.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!