Background: Soy lecithin is widely used as an emulsifier, not only in topical skin care products but also in various drugs administered either topically, orally, or intravenously or by inhalation. Patients strongly allergic to soy and/or peanuts can develop an anaphylactic reaction when exposed to soy lecithin.
Method: We report a 3-year-old asthmatic boy, allergic to peanuts, who was treated at the emergency department for an exacerbation of asthma following an upper respiratory tract infection. Within an hour after receiving the second of two inhalations of an ipratropium bromide (Atrovent) metered dose inhaler, he developed respiratory distress and generalized urticaria, an adverse event that regressed within 48 hours of withdrawal of the suspected drug. Soy lecithin, contained as an excipient in the metered dose inhaler, was strongly suspected of being responsible for this reaction.
Conclusion: Drug products containing soy lecithin can cause severe allergic reactions in patients allergic to peanuts or soy. Physicians should be aware that adverse drug reactions can be due to both the active medical component and the excipient ingredients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2310/7750.2007.00031 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cationized albumin conjugated solid lipid nanoparticles as vectors for delivery of albendazole against cystic echinococcosis.
Parasit Vectors
December 2024
Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Background: Cystic echinococcosis (CE) is a common neglected parasitic disease. Nanoparticles containing drugs have been widely utilized in various formulations for several purposes, including improving the bioavailability of drugs by increasing the solubility and dissolution rate of the nanoparticles. The purpose of this study was to evaluate the effects of solid lipid nanoparticles containing albendazole and conjugated to albumin (B-SLN + ABZ) as a novel treatment approach for hydatid cysts in vivo.
View Article and Find Full Text PDFThe Influence of Different Butter Type, Their Fatty Acid Composition and Melting Enthalpy on the Viability Rate of GG Directly After the Spray-Drying Process and During Storage of Powders.
Foods
November 2024
Center of Bioimmobilisation and Innovative Packaging Materials, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology in Szczecin, Klemensa Janickiego 35, 71-270 Szczecin, Poland.
The present work reports on the microencapsulation of GG (LGG) by the spray-drying process using a solution of starch, whey protein concentrate (WPC), soy lecithin and ascorbic acid as a carrier, with addition of different types of butters. The aim of this study was to examine the protective mechanism of six different butter samples on the viability rate of LGG bacteria directly after the spray-drying process and during storage for 4 weeks at 4 °C and 20 °C (±1 °C) based on hypothetical factors-the fatty acid's chemical character and content, and its melting enthalpy. The viability of bacteria, moisture content, water activity, color properties, morphology, particle size of powder, melting enthalpy of butters and their fatty acids composition were evaluated.
View Article and Find Full Text PDFEffects of new lipid ingredients during pregnancy and lactation on rat offspring brain gene expression.
Food Funct
December 2024
Department of Physiology, Faculty of Biology, University of Murcia, Campus of Espinardo, 30100 Murcia, Spain.
Maternal dietary fat intake during pregnancy and lactation may influence the bioavailability of essential lipophilic nutrients, such as docosahexaenoic acid (DHA), that are important for both the mother and her child's development. This study aimed to evaluate the effects of different maternal fat diets on fat absorption and pup brain development by analyzing gene expression. Rats were fed diets with different lipid matrices during pregnancy and lactation: diet A, mono and diglycerides (MDG) + soy lecithin phospholipids (PL); diet B, MDG + soy lecithin PL + milk-derived PL; and a control diet.
View Article and Find Full Text PDFQuantification of emulsifier adsorption onto sugar crystals dispersed in vegetable oil and associated effects on flow behaviour.
Food Res Int
January 2025
Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, Ontario, Canada. Electronic address:
Emulsifiers play an essential role in the flow behaviour of confectionery products such as chocolate. This research associated emulsifier adsorption onto sugar crystals and its effects on the flow properties of model sugar-in-oil suspensions. A new method to quantify emulsifier adsorption onto sugar crystals dispersed in oil was developed by exploiting the relationship between oil-water interfacial tension and unadsorbed emulsifier in the continuous oil phase.
View Article and Find Full Text PDFImpact of non-ionic surfactants on release kinetics, toxicity and colloidal characteristics of benznidazole self-emulsifying delivery system evidenced by flow field-flow fractionation.
J Chromatogr A
January 2025
Laboratory of Pharmaceutics and Nanotechnology (LDGNano), School of Pharmacy, Federal University of Ouro Preto, Minas Gerais 35400-000, Brazil. Electronic address:
Chagas disease is the major cause of death by cardiomyopathy in Latin America. Benznidazole (BZN) tablets are the standard of care for Chagas disease, and recently, self-emulsifying systems (SEDDS) have shown promising efficacy as the BZN delivery system, particularly for pediatric use. However, the comparative effects of surfactants on the physicochemical properties of SEDDS have been poorly investigated to date.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!