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Artificial Oxygen Carriers Save Lives in Expanded Access Use: Three Cases when Blood Was Not an Option.
Am J Ther
January 2025
Anesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Clinical Features: Sickle cell patients may develop a multitude of antibodies and experience life-threatening events with transfusion such as hyperhemolysis syndrome or delayed hemolytic transfusion reaction. Further transfusion may not be possible in such cases.
Therapeutic Challenge: When conventional blood products are not available for transfusion yet the patient requires additional oxygen-carrying support, artificial oxygen carriers may be required.
How do we manage hyperhemolysis syndrome.
Transfusion
October 2024
Division of Transfusion Medicine and Hemostasis, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Article Synopsis
- - Hyperhemolysis syndrome (HHS) is a severe condition that leads to anemia by destroying both donor and patient red blood cells, primarily occurring after blood transfusions, and can have serious health consequences.
- - A team from Transfusion Medicine and Hematology developed a consensus protocol for diagnosing and managing HHS, which includes specific diagnostic criteria like recent transfusion history, hemoglobin drop, and laboratory signs of hemolysis.
- - The study emphasizes a detailed management strategy aimed at improving blood cell production while reducing the immune response to enhance patient outcomes based on current research and clinical practices.
Hyperbaric Oxygen Therapy during Pregnancy for Critical Anemia Secondary to Sickle Cell Disease with Post-Transfusion Hyperhemolysis: A Case Report.
Hematol Rep
August 2024
Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Sickle cell disease is the most common human monogenetic disease, and its risks are amplified during pregnancy. : This report describes a 35-year-old woman with HgbSS sickle cell disease who developed hyperhemolysis syndrome after undergoing an exchange transfusion during pregnancy. In addition to conventional medical treatment, the patient received prepartum hyperbaric oxygen therapy (HBOT), totaling 17 treatments for the indication of severe anemia.
View Article and Find Full Text PDFHyperhemolysis syndrome in a case of sickle cell disease.
Asian J Transfus Sci
December 2022
Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra, India.
Eculizumab for management of hyperhemolysis syndrome in pediatric patients with sickle cell disease: A single-center case series.
Pediatr Blood Cancer
August 2024
Division of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA.
Chronic hemolytic anemia and vascular occlusion are hallmarks of sickle cell disease (SCD). Blood transfusions are critical for supportive and preventive management of SCD complications. Patients with SCD are at risk for hyperhemolysis syndrome (HHS), a subtype of delayed hemolytic transfusion reactions.
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