AI Article Synopsis
- The exact way picornaviruses penetrate cell membranes is not well-understood, but the small protein VP4 is believed to be important in this process.
- Research has shown that VP4 from human rhinovirus 16 can interact with liposomes and make their membranes more permeable.
- This study reinforces the idea that VP4 is crucial for the entry of picornaviruses into host cells.
Article Abstract
In common with all nonenveloped viruses, the mechanism of picornavirus membrane penetration during cell entry is poorly understood. The small, myristylated capsid protein VP4 has been implicated in this process. Here we show that recombinant VP4 of human rhinovirus 16 has the ability to associate with and induce membrane permeability in otherwise intact liposomes. This provides further evidence that VP4 plays a key role in picornavirus cell entry.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293005 | PMC |
| http://dx.doi.org/10.1128/JVI.01070-07 | DOI Listing |
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