In this paper we consider the determination of the structure of the high-order Boltzmann machine (HOBM), a stochastic recurrent network for approximating probability distributions. We obtain the structure of the HOBM, the hypergraph of connections, from conditional independences of the probability distribution to model. We assume that an expert provides these conditional independences and from them we build independence maps, Markov and Bayesian networks, which represent conditional independences through undirected graphs and directed acyclic graphs respectively. From these independence maps we construct the HOBM hypergraph. The central aim of this paper is to obtain a minimal hypergraph. Given that different orderings of the variables provide in general different Bayesian networks, we define their intersection hypergraph. We prove that the intersection hypergraph of all the Bayesian networks (N!) of the distribution is contained by the hypergraph of the Markov network, it is more simple, and we give a procedure to determine a subset of the Bayesian networks that verifies this property. We also prove that the Markov network graph establishes a minimum connectivity for the hypergraphs from Bayesian networks.
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http://dx.doi.org/10.1109/72.641458 | DOI Listing |
J Infect
January 2025
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States.
Background: Pneumococcal conjugate vaccines (PCVs) introduced in childhood national immunization programs lowered vaccine-type invasive pneumococcal disease (IPD), but replacement with non-vaccine-types persisted throughout the PCV10/13 follow-up period. We assessed PCV10/13 impact on pneumococcal meningitis incidence globally.
Methods: The number of cases with serotyped pneumococci detected in cerebrospinal fluid and population denominators were obtained from surveillance sites globally.
Environ Toxicol Chem
January 2025
School of Environmental Engineering, University of Seoul, Seoul, Korea.
An adverse outcome pathway (AOP) framework maps the sequence of events leading to adverse outcomes from chemical exposures, providing a mechanistic understanding often absent in traditional methods. The quantitative AOP (qAOP) advances AOP by integrating quantitative data and mathematical modeling, thereby providing a more precise comprehension of relationships between molecular initiating events, key events, and adverse outcomes. This review critically examines three primary methodologies: systems toxicology, regression modeling, and Bayesian network modeling, highlighting their strengths, limitations, and specific data requirements within toxicology.
View Article and Find Full Text PDFOncology
January 2025
Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Introduction: Temozolomide (TMZ) is a widely used chemotherapy agent for the treatment of malignant gliomas and other brain tumors. Despite its established therapeutic benefits, there is an ongoing need to understand better its safety profile, particularly in real-world clinical settings. This study aimed to identify critical adverse drug reactions (ADRs) associated with TMZ by utilizing the FDA Adverse Event Reporting System (FAERS) database, thereby providing valuable safety insights for clinical practice.
View Article and Find Full Text PDFJ Environ Manage
January 2025
School of Economics and Management, Beijing Jiaotong University, 100091, Beijing, China. Electronic address:
Chinese construction enterprises are at a pivotal point in their transition to sustainable development, with Environmental, Social, and Governance (ESG) emerging as a key driver. However, limited understanding of ESG mechanisms hampers effective management strategies. To address this challenge, this study constructs an ESG introduction mechanism framework based on Bayesian networks and machine learning algorithms.
View Article and Find Full Text PDFClin Epigenetics
January 2025
Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Alcohol consumption is an important risk factor for multiple diseases. It is typically assessed via self-report, which is open to measurement error through recall bias. Instead, molecular data such as blood-based DNA methylation (DNAm) could be used to derive a more objective measure of alcohol consumption by incorporating information from cytosine-phosphate-guanine (CpG) sites known to be linked to the trait.
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