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The multi-herbal decoction SH003 alleviates LPS-induced acute lung injury by targeting inflammasome and extracellular traps in neutrophils.
Phytomedicine
October 2024
Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea; Korean Medicine-Based Drug Repositioning Cancer Research Center, Kyung Hee University, Seoul, Republic of Korea. Electronic address:
Article Synopsis
- Acute lung injury (ALI), caused by various factors including COVID-19, can be mitigated with the herbal formula SH003, which contains Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii, known for anti-inflammatory properties.
- The study utilized computer-based analysis and tested SH003 on mice with septic ALI, demonstrating its ability to reduce inflammation and mortality when compared to the known treatment dexamethasone.
- Results indicated that SH003 inhibits harmful immune responses in the lungs by suppressing inflammasome activation and streaming down neutrophil extracellular trap (NET) formation, marking it as a promising treatment for septic ALI.
Anti-proliferative and anti-inflammatory effects of the application of baclofen cream, a GABA receptor agonist, on skin inflammation in mice.
Eur J Pharmacol
September 2023
Department of Pharmacology, Universidade Federal Do Paraná, Curitiba, PR, Brazil. Electronic address:
Previous studies have demonstrated the role of γ-aminobutyric acid type B (GABA) receptors in skin-related conditions and pain. However, most studies have focused on the main effects of GABA on the central nervous system. Therefore, this study has aimed to determine the potential topical anti-inflammatory and anti-proliferative effects of baclofen cream in an inflammatory skin disease model.
View Article and Find Full Text PDFThe influence of COVID-19 on colorectal cancer was investigated using bioinformatics and systems biology techniques.
Front Med (Lausanne)
June 2023
Division of Liver Surgery, Department of General Surgery and Laboratory of Liver Surgery, and State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Introduction: Coronavirus disease 2019 (COVID-19) is a global pandemic and highly contagious, posing a serious threat to human health. Colorectal cancer (CRC) is a risk factor for COVID-19 infection. Therefore, it is vital to investigate the intrinsic link between these two diseases.
View Article and Find Full Text PDFExpression of SARS-CoV-2 receptor angiotensin-converting enzyme 2 by activating protein-1 in human mast cells.
Cell Immunol
April 2023
Biochip Research Center, Hoseo University, Asan 31499, Republic of Korea; Department of Bio-Convergence System, Graduate School, Hoseo University, Asan 31499, Republic of Korea. Electronic address:
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection activates mast cells and induces a cytokine storm, leading to severe Coronavirus disease in 2019 (COVID-19). SARS-CoV-2 employs angiotensin-converting enzyme 2 (ACE2) for cell entry. In the present study, the expression of ACE2 and its mechanism in activated mast cells were studied utilizing the human mast cell line, HMC-1 cells and it was elucidated whether dexamethasone used as a treatment for COVID-19 could regulate ACE2 expression.
View Article and Find Full Text PDFHDAC8 regulates protein kinase D phosphorylation in skeletal myoblasts in response to stress signaling.
Biochem Biophys Res Commun
April 2023
Department of Nutrition, The University of Nevada Reno, Reno, NV, 89557, USA; Cellular and Molecular Biology, The University of Nevada Reno, Reno, NV, 89557, USA; Center of Biomedical Research Excellence for Molecular and Cellular Signal Transduction in the Cardiovascular System, The University of Nevada Reno, Reno, NV, 89557, USA. Electronic address:
Skeletal muscle differentiation involves activation of quiescent satellite cells to proliferate, differentiate and fuse to form new myofibers; this requires coordination of myogenic transcription factors. Myogenic transcription is tightly regulated by various intracellular signaling pathways, which include members of the protein kinase D (PKD) family. PKD is a family of serine-threonine kinases that regulate gene expression, protein secretion, cell proliferation, differentiation and inflammation.
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