Objective: The purpose of this pilot study was to investigate the kinematics of the presumed-to-be-unaffected upper limbs of people with brain injury (BI) compared with people without brain injury (WBI) during reaching.
Method: Seventeen people with BI with no apparent motor deficit and 17 people WBI were measured and compared. A six-camera motion analysis system was used to determine movement duration, average speed, and smoothness during reaching.
Results: The group of people with BI was found to be significantly longer in movement duration (p < .0001), were slower in average speed (p < .0001), and had decreased smoothness (p < .0001) during reaching than the group of people WBI.
Conclusion: The results suggest that people with BI may have undetected motor deficit in their presumed-to-be-unaffected upper extremities. Further research is needed to explore the upper-limb motor performance and the impact on function and safety.
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http://dx.doi.org/10.5014/ajot.62.1.46 | DOI Listing |
Appl Neuropsychol Child
January 2025
Department of Psychology and Neuroscience Center, Brigham Young University, Provo, USA.
Chronic stage neuropsychological assessments of children with severe TBI typically center around a referral question and focus on assessing cognitive, behavioral, and emotional functioning, making differential diagnoses, and planning treatment. When severe TBI-related neurological deficits are subtle and fall outside commonly assessed behavioral indicators, as can happen with theory of mind and social information processing, they can go unobserved and subsequently fail to be assessed. Additionally, should chronic stage cognitive, behavioral, and emotional assessment findings fall within the average to above average range, a child experiencing ongoing significant unassessed severe TBI-related subtle deficits could be mistakenly judged to have "recovered" from their injury; and to be experiencing no significant ongoing residual neurological deficits.
View Article and Find Full Text PDFNeurosurg Rev
January 2025
Lab in Biotechnology and Biosignal Transduction, Department of Orthodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-77, Tamil Nadu, India.
Histol Histopathol
February 2025
Department of Intensive Care Unit, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong, China.
The authors regret the paper was published with an error in Figure 3B sh-NC+HI group. The H&E image in 3B sh-NC+HI group should be corrected as follows. This correction has no influence on the conclusion and the main text of the article.
View Article and Find Full Text PDFFront Aging Neurosci
January 2025
School of Medicine, Yunnan University, Kunming, China.
Background: Traumatic brain injury (TBI) can generally be divided into focal damage and diffuse damage, and neonate Hypoxia-Ischemia Brain Damage (nHIBD) is one of the causes of diffuse damage. Patients with nHIBD are at an increased risk of developing Alzheimer's disease (AD). However, the shared pathogenesis of patients affected with both neurological disorders has not been fully elucidated.
View Article and Find Full Text PDFBiomater Transl
November 2024
Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, Tongji Hospital affiliated to Tongji University, School of Life Science and Technology, Tongji University, Shanghai, China.
Stem cell-derived spinal cord organoids (SCOs) have revolutionised the study of spinal cord development and disease mechanisms, offering a three-dimensional model that recapitulates the complexity of native tissue. This review synthesises recent advancements in SCO technology, highlighting their role in modelling spinal cord morphogenesis and their application in neurodegenerative disease research. We discuss the methodological breakthroughs in inducing regional specification and cellular diversity within SCOs, which have enhanced their predictive ability for drug screening and their relevance in mimicking pathological conditions such as neurodegenerative diseases and neuromuscular disorders.
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